Journal article
Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma
The Journal of experimental medicine, v 185(12), pp 2143-2156
16 Jun 1997
PMID: 9182686
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchial eosinophils and striking pathologic changes including the expansion of bronchusassociated lymphoid tissue (BALT), goblet cell hyperplasia, epithelial hypertrophy, and focal collagen deposition. These changes were also accompanied by eosinophil infiltration of the airway lumen. In addition, transgenic animals displayed airway hyperresponsiveness to methacholine in the absence of aerosolized antigen challenge. These findings demonstrate that lung-specific IL-5 expression can induce pathologic changes characteristic of asthma and may provide useful models to evaluate the efficacy of potential respiratory disease therapies or pharmaceuticals.
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Details
- Title
- Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma
- Creators
- James J Lee - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImMichael P McGarry - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImSteven C Farmer - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImKaren L Denzler - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImKirsten A Larson - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImPatricia E Carrigan - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImIna E Brenneise - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImMargaret A Horton - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImAngela Haczku - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImErwin W Gelfand - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImGeorge D Leikauf - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for ImNancy A Lee - From the Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, Arizona 85259; Department of Laboratory Animal Resources, Roswell Park Cancer Institute, Buffalo, New York 14263; Department of Environmental Health, Molecular and Cellular Physiology and Medicine, University of Cincinnati, Cincinnati, Ohio 45267; and Department of Pediatrics, National Jewish Center for Im
- Publication Details
- The Journal of experimental medicine, v 185(12), pp 2143-2156
- Publisher
- Rockefeller University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1997XF79100013
- Scopus ID
- 2-s2.0-17444454662
- Other Identifier
- 991014877770004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental