Journal article
Interleukin 6 modulation of second messenger systems in anterior pituitary cells
Life sciences (1973), v 51(16), pp 1243-1248
1992
PMID: 1406045
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We investigated the effect of interleukin-6 (IL-6) on second messenger systems in anterior pituitary (AP) cells. The acute exposition of membranes derived from the pituitary gland to IL-6 did not modify basal and forskolin-stimulated adenylate cyclase (AC) activity, as well as inositol phosphate (IP) production and free [Ca
++]
i. Preincubation of AP cells with IL-6 for 20 min did not affect basal second messengers levels, while completely abolished the stimulation by VIP of AC activity, partially inhibited forskolin-stimulated cAMP formation and reduced TRH-stimulated IP production. Finally, the pretreatment of AP cells for 20 min with IL-6 also reduced the TRH-induced rise in free [Ca
++]
i.
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Details
- Title
- Interleukin 6 modulation of second messenger systems in anterior pituitary cells
- Creators
- Maurizio Grimaldi - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, ItalyOlimpia Meucci - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, ItalyAntonella Scorziello - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, ItalyTullio Florio - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, ItalyCarmelo Ventra - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, ItalyRenato De Mercato - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, ItalyGennaro Schettini - Dip. di Scienza delle Communicazioni Umane, Sezione di Farmacologia, Italy
- Publication Details
- Life sciences (1973), v 51(16), pp 1243-1248
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1992JM66700001
- Scopus ID
- 2-s2.0-0026742871
- Other Identifier
- 991020111343304721
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- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy