Journal article
Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
Journal of neurophysiology, v 105(6), pp 3080-3091
Jun 2011
PMID: 21471394
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hypertension elicited by chronic intermittent hypoxia (CIH) is associated with elevated activity of the thoracic sympathetic nerve (tSN) that exhibits an enhanced respiratory modulation reflecting a strengthened interaction between respiratory and sympathetic networks within the brain stem. Expiration is a passive process except for special metabolic conditions such as hypercapnia, when it becomes active through phasic excitation of abdominal motor nerves (AbN) in late expiration. An increase in CO
2
evokes late-expiratory (late-E) discharges phase-locked to phrenic bursts with the frequency increasing quantally as hypercapnia increases. In rats exposed to CIH, the late-E discharges synchronized in AbN and tSN emerge in normocapnia. To elucidate the possible neural mechanisms underlying these phenomena, we extended our computational model of the brain stem respiratory network by incorporating a population of presympathetic neurons in the rostral ventrolateral medulla that received inputs from the pons, medullary respiratory compartments, and retrotrapezoid nucleus/parafacial respiratory group (RTN/pFRG). Our simulations proposed that CIH conditioning increases the CO
2
sensitivity of RTN/pFRG neurons, causing a reduction in both the CO
2
threshold for emerging the late-E activity in AbN and tSN and the hypocapnic threshold for apnea. Using the in situ rat preparation, we have confirmed that CIH-conditioned rats under normal conditions exhibit synchronized late-E discharges in AbN and tSN similar to those observed in control rats during hypercapnia. Moreover, the hypocapnic threshold for apnea was significantly lowered in CIH-conditioned rats relative to that in control rats. We conclude that CIH may sensitize central chemoreception and that this significantly contributes to the neural impetus for generation of sympathetic activity and hypertension.
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Details
- Title
- Intermittent hypoxia-induced sensitization of central chemoreceptors contributes to sympathetic nerve activity during late expiration in rats
- Creators
- Yaroslav I Molkov - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PennsylvaniaDaniel B Zoccal - Department of Physiology, School of Medicine of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, Sao PauloDavi J. A Moraes - Department of Physiology, School of Medicine of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, Sao PauloJulian F. R Paton - School of Physiology and Pharmacology, Bristol Heart Institute, University of Bristol, Bristol, United KingdomBenedito H Machado - Department of Physiology, School of Medicine of Ribeirão Preto, University of Sao Paulo, Ribeirão Preto, Sao PauloIlya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania
- Publication Details
- Journal of neurophysiology, v 105(6), pp 3080-3091
- Publisher
- American Physiological Society; Bethesda, MD
- Grant note
- R01 NS057815; R01 NS069220; R33 HL087379 / National Institutes of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000291716900044
- Scopus ID
- 2-s2.0-79959354634
- Other Identifier
- 991014878445104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Physiology