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Interobserver variability associated with the MIB‐1 labeling index
Journal article   Open access   Peer reviewed

Interobserver variability associated with the MIB‐1 labeling index

Dana Marie Grzybicki, Yulin Liu, Steven A. Moore, Henry G. Brown, Jan F. Silverman, Frank D'Amico and Stephen S. Raab
Cancer, v 92(10), pp 2720-2726
15 Nov 2001
DOI: https://doi.org/10.1002/1097-0142(20011115)92:10<2720::AID-CNCR1626>3.0.CO;2-Z
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1002/1097-0142(20011115)92:10<2720::aid-cncr1626>3.0.co;2-zView
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open
url
https://doi.org/10.1002/1097-0142(20011115)92:10<2720::AID-CNCR1626>3.0.CO;2-ZView
Published, Version of Record (VoR) Open

Abstract

astroglioma brain tumor interobserver variability MIB‐1 prognosis
BACKGROUND The use of the MIB‐1 labeling index (LI) as a potential prognostic marker for patients with primary brain tumors is controversial. Many studies advocating its prognostic usefulness have suggested discrete MIB‐1 LI cut‐off values, above which patients have significantly worse outcomes. However, interobserver variability associated previously with MIB‐1 LI calculation has not been reported despite the fact that the degree of interobserver variability impacts the clinical usefulness of such cut‐off values. METHODS MIB‐1 LIs were calculated independently using a standardized protocol by six pathologist observers for 50 astrocytic gliomas of varying grades. The level of interobserver agreement was determined by calculating kappa statistics for pairwise pathologist comparisons using MIB‐1 LI cut‐off values of 2.5%, 5.0%, 8.0%, 11.0%, and 15.0%. Spearman rank correlation coefficients were used to assess the pairwise associations between observer MIB‐1 LIs. RESULTS Although there was general agreement among pathologists regarding whether an MIB‐1 LI for a given astroglial tumor was low, moderate, or high based on the analysis of correlation, a high level of interobserver variability was associated with the determination of specific MIB‐1 LIs. The highest level of agreement occurred using a cut‐off value of 5.0%, with pairwise kappa statistics for this value ranging from 0.52 to 0.80. CONCLUSIONS The high level of interobserver variability suggests that proposed discrete MIB‐1 LI prognostic cut‐off values most likely are not useful clinically for predicting outcome for individual patients with primary brain tumors. Further prospective studies are needed investigating the prognostic usefulness of MIB‐1 LI ranges that optimize interobserver agreement. Cancer 2001;92:2720–6. © 2001 American Cancer Society. The high level interobserver variability in the MIB‐1 labeling index (LI) measured in this study suggests that proposed discrete MIB‐1 LI prognostic cut‐off values are not useful clinically for predicting outcome for individual patients with primary brain tumors. Further prospective studies are needed to investigate the prognostic usefulness of MIB‐1 LI ranges that optimize interobserver agreement.

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Collaboration types
Domestic collaboration
Web of Science research areas
Oncology
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