Journal article
Interplay Between microRNAs, Toll-like Receptors, and HIV-1: Potential Implications in HIV-1 Replication and Chronic Immune Activation
Discovery medicine, v 18(97), pp 15-27
01 Jul 2014
PMID: 25091485
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
MicroRNAs (miRNAs) are important cellular, small non-coding RNAs that regulate host gene expression and have well-characterized roles in inflammation and infectious diseases. It has become apparent as well that cellular miRNAs can play crucial roles in controlling HIV-1 infection and replication. Whether HIV-1 encodes and is able to express viral miRNAs in infected cells remains controversial. HIV-1 can manipulate the biogenesis of miRNAs as well as the expression profiles of cellular miRNAs. Toll-Like receptors (TLRs) are important pathogen recognition receptors that sense invading pathogens orchestrating innate and adaptive immune responses. Innate immune recognition of HIV-1 infection leads to activation of TLR7/8. Recent evidence has shown that certain miRNAs can also be recognized by TLR7/8 leading to immune activation. However, the potential TLR7/8-mediated recognition of HIV-1 encoded miRNAs and/or cellular miRNAs modulated in HIV-1 infected cells has not been experimentally explored. In this review, we summarize the current literature on HIV-1 infection and miRNAs. Furthermore, we underscore the need for future research on potential miRNA-induced activation of TLR7/8, which might contribute to the chronic immune activation observed in HIV-1 infected patients.
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Details
- Title
- Interplay Between microRNAs, Toll-like Receptors, and HIV-1: Potential Implications in HIV-1 Replication and Chronic Immune Activation
- Creators
- Gokul Swaminathan - Drexel Univ, Coll Med, Inst Mol Med & Infect Dis, Dept Microbiol & Immunol, Philadelphia, PA 19102 USASonia Navas-Martin - Drexel UniversityJulio Martin-Garcia - Drexel Univ, Coll Med, Inst Mol Med & Infect Dis, Dept Microbiol & Immunol, Philadelphia, PA 19102 USA
- Publication Details
- Discovery medicine, v 18(97), pp 15-27
- Publisher
- Discovery Medicine
- Number of pages
- 13
- Grant note
- R21AI098549 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) NS065727; AI098549 / Public Health Service; United States Department of Health & Human Services; United States Public Health Service Drexel University College of Medicine's Professional Enrichment and Growth Grant National Institute of Allergy and Infectious Disease; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01NS065727 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000345398900002
- Scopus ID
- 2-s2.0-84925884554
- Other Identifier
- 991019167316804721
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- Web of Science research areas
- Medicine, Research & Experimental