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Journal article
Interplay of polygenic liability with birth-related, somatic, and psychosocial factors in anorexia nervosa risk: a nationwide study
Psychological medicine, p1
13 Feb 2024
PMID: 38347808
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although several types of risk factors for anorexia nervosa (AN) have been identified, including birth-related factors, somatic, and psychosocial risk factors, their interplay with genetic susceptibility remains unclear. Genetic and epidemiological interplay in AN risk were examined using data from Danish nationwide registers. AN polygenic risk score (PRS) and risk factor associations, confounding from AN PRS and/or parental psychiatric history on the association between the risk factors and AN risk, and interactions between AN PRS and each level of target risk factor on AN risk were estimated.
Participants were individuals born in Denmark between 1981 and 2008 including nationwide-representative data from the iPSYCH2015, and Danish AN cases from the Anorexia Nervosa Genetics Initiative and Eating Disorder Genetics Initiative cohorts. A total of 7003 individuals with AN and 45 229 individuals without a registered AN diagnosis were included. We included 22 AN risk factors from Danish registers.
Risk factors showing association with PRS for AN included urbanicity, parental ages, genitourinary tract infection, and parental socioeconomic factors. Risk factors showed the expected association to AN risk, and this association was only slightly attenuated when adjusted for parental history of psychiatric disorders or/and for the AN PRS. The interaction analyses revealed a differential effect of AN PRS according to the level of the following risk factors: sex, maternal age, genitourinary tract infection, C-section, parental socioeconomic factors and psychiatric history.
Our findings provide evidence for interactions between AN PRS and certain risk-factors, illustrating potential diverse risk pathways to AN diagnosis.
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Details
- Title
- Interplay of polygenic liability with birth-related, somatic, and psychosocial factors in anorexia nervosa risk: a nationwide study
- Creators
- Natalie M Papini - University of North Carolina at Chapel HillEmily Presseller - Drexel UniversityCynthia M Bulik - Karolinska InstitutetKatrine Holde - Aarhus UniversityJanne T Larsen - Aarhus UniversityLaura M Thornton - University of North Carolina at Chapel HillClara Albiñana - Aarhus UniversityBjarni J Vilhjálmsson - Broad InstitutePreben B Mortensen - Aarhus UniversityZeynep Yilmaz - Aarhus UniversityLiselotte V Petersen - Aarhus University
- Publication Details
- Psychological medicine, p1
- Publisher
- Cambridge University Press
- Grant note
- 1R01MH122869-01 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001160953000001
- Scopus ID
- 2-s2.0-85187286461
- Other Identifier
- 991021852272104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Clinical