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Interrelationship of cytokines, hypothalamic-pituitary-adrenal axis hormones, and psychosocial variables in the prediction of preterm birth
Journal article   Open access   Peer reviewed

Interrelationship of cytokines, hypothalamic-pituitary-adrenal axis hormones, and psychosocial variables in the prediction of preterm birth

B D Pearce, J Grove, E A Bonney, N Bliwise, D J Dudley, D E Schendel and P Thorsen
Gynecologic and obstetric investigation, v 70(1)
2010
DOI: https://doi.org/10.1159/000284949
PMID: 20160447
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1159/000284949View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Adolescent Adult C-Reactive Protein - immunology C-Reactive Protein - metabolism Corticotropin-Releasing Hormone - blood Corticotropin-Releasing Hormone - immunology Cytokines - blood Cytokines - immunology Female Humans Hydrocortisone - blood Hydrocortisone - immunology Hypothalamo-Hypophyseal System - immunology Infant, Newborn Inflammation - epidemiology Inflammation - immunology Inflammation - psychology Interleukin-10 - blood Interleukin-10 - immunology Interleukin-6 - blood Interleukin-6 - immunology Intramolecular Oxidoreductases - blood Intramolecular Oxidoreductases - immunology Macrophage Migration-Inhibitory Factors - blood Macrophage Migration-Inhibitory Factors - immunology Neuroimmunomodulation - immunology Pituitary-Adrenal System - immunology Pregnancy Premature Birth - epidemiology Premature Birth - immunology Premature Birth - psychology Psychology Risk Factors Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - immunology Young Adult
To examine the relationship of biological mediators (cytokines, stress hormones), psychosocial, obstetric history, and demographic factors in the early prediction of preterm birth (PTB) using a comprehensive logistic regression model incorporating diverse risk factors. In this prospective case-control study, maternal serum biomarkers were quantified at 9-23 weeks' gestation in 60 women delivering at <37 weeks compared to 123 women delivering at term. Biomarker data were combined with maternal sociodemographic factors and stress data into regression models encompassing 22 preterm risk factors and 1st-order interactions. Among individual biomarkers, we found that macrophage migration inhibitory factor (MIF), interleukin-10, C-reactive protein (CRP), and tumor necrosis factor-alpha were statistically significant predictors of PTB at all cutoff levels tested (75th, 85th, and 90th percentiles). We fit multifactor models for PTB prediction at each biomarker cutoff. Our best models revealed that MIF, CRP, risk-taking behavior, and low educational attainment were consistent predictors of PTB at all biomarker cutoffs. The 75th percentile cutoff yielded the best predicting model with an area under the ROC curve of 0.808 (95% CI 0.743-0.874). Our comprehensive models highlight the prominence of behavioral risk factors for PTB and point to MIF as a possible psychobiological mediator.

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35 citations in Web of Science
41 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Obstetrics & Gynecology
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