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Published, Version of Record (VoR)CC BY-NC V4.0, Open
Journal article
Interstitial fluid flow in cancer: implications for disease progression and treatment
Cancer management and research, v 6(1), pp 317-328
01 Jan 2014
PMID: 25170280
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
As cancer progresses, a dynamic microenvironment develops that creates and responds to cellular and biophysical cues. Increased intratumoral pressure and corresponding increases in interstitial flow from the tumor bulk to the healthy stroma is an observational hallmark of progressing cancers. Until recently, the role of interstitial flow was thought to be mostly passive in the transport and dissemination of cancer cells to metastatic sites. With research spanning the past decade, we have seen that interstitial flow has a promigratory effect on cancer cell invasion in multiple cancer types. This invasion is one mechanism by which cancers can resist therapeutics and recur, but the role of interstitial flow in cancer therapy is limited to the understanding of transport of therapeutics. Here we outline the current understanding of the role of interstitial flow in cancer and the tumor microenvironment through cancer progression and therapy. We also discuss the current role of fluid flow in the treatment of cancer, including drug transport and therapeutic strategies. By stating the current understanding of interstitial flow in cancer progression, we can begin exploring its role in therapeutic failure and treatment resistance.
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Details
- Title
- Interstitial fluid flow in cancer: implications for disease progression and treatment
- Creators
- Jennifer M. Munson - University of VirginiaAdrian C. Shieh - Drexel University
- Publication Details
- Cancer management and research, v 6(1), pp 317-328
- Publisher
- Dove Medical Press Ltd
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000209885400028
- Scopus ID
- 2-s2.0-84925258395
- Other Identifier
- 991019168120204721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology