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Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice
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Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice

Víctor Rovira and Emilio Geijo-Barrientos
PloS one, v 11(3), pp e0150092-e0150092
2016
DOI: https://doi.org/10.1371/journal.pone.0150092
PMID: 26930051
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1371/journal.pone.0150092View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Amphetamines - pharmacology Animals Bicuculline - pharmacology Electric Stimulation Electrophysiological Phenomena - drug effects GABA-A Receptor Antagonists - pharmacology Gyrus Cinguli - drug effects Gyrus Cinguli - metabolism Gyrus Cinguli - physiology Male Mice, Inbred C57BL Receptor, Serotonin, 5-HT1B - metabolism Receptor, Serotonin, 5-HT2A - metabolism Serotonin - pharmacology Serotonin Receptor Agonists - pharmacology Time Factors
Disinhibition of the cortex (e.g., by GABA -receptor blockade) generates synchronous and oscillatory electrophysiological activity that propagates along the cortex. We have studied, in brain slices of the cingulate cortex of mice (postnatal age 14-20 days), the propagation along layer 2/3 as well as the interhemispheric propagation through the corpus callosum of synchronous discharges recorded extracellularly and evoked in the presence of 10 μM bicuculline by electrical stimulation of layer 1. The latency of the responses obtained at the same distance from the stimulus electrode was longer in anterior cingulate cortex (ACC: 39.53 ± 2.83 ms, n = 7) than in retrosplenial cortex slices (RSC: 21.99 ± 2.75 ms, n = 5; p<0.05), which is equivalent to a lower propagation velocity in the dorso-ventral direction in ACC than in RSC slices (43.0 mm/s vs 72.9 mm/s). We studied the modulation of this propagation by serotonin. Serotonin significantly increased the latency of the intracortical synchronous discharges (18.9% in the ipsilateral hemisphere and 40.2% in the contralateral hemisphere), and also increased the interhemispheric propagation time by 86.4%. These actions of serotonin were mimicked by the activation of either 5-HT1B or 5-HT2A receptors, but not by the activation of the 5-HT1A subtype. These findings provide further knowledge about the propagation of synchronic electrical activity in the cerebral cortex, including its modulation by serotonin, and suggest the presence of deep differences between the ACC and RSC in the structure of the local cortical microcircuits underlying the propagation of synchronous discharges.

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Neurosciences
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