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Journal article
Intra-axonal protein synthesis - a new target for neural repair?
Neural regeneration research, v 11(9), pp 1365-1367
01 Sep 2016
PMID: 27857722
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although initially argued to be a feature of immature neurons with incomplete polarization, there is clear evidence that neurons in the peripheral nervous system retain the capacity for intra-axonal protein synthesis well into adulthood. This localized protein synthesis has been shown to contribute to injury signaling and axon regeneration in peripheral nerves. Recent works point to potential for protein synthesis in axons of the vertebrate central nervous system. mRNAs and protein synthesis machinery have now been documented in lamprey, mouse, and rat spinal cord axons. Intra-axonal protein synthesis appears to be activated in adult vertebrate spinal cord axons when they are regeneration-competent. Rat spinal cord axons regenerating into a peripheral nerve graft contain mRNAs and markers of activated translational machinery. Indeed, levels of some growth-associated mRNAs in these spinal cord axons are comparable to the regenerating sciatic nerve. Markers of active translation tend to decrease when these axons stop growing, but can be reactivated by a second axotomy. These emerging observations raise the possibility that mRNA transport into and translation within axons could be targeted to facilitate regeneration in both the peripheral and central nervous systems.
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Details
- Title
- Intra-axonal protein synthesis - a new target for neural repair?
- Creators
- Jeffery L. Twiss - University of South CarolinaAshley L. Kalinski - University of South CarolinaRahul Sachdeva - Drexel UniversityJohn D. Houle - Drexel University
- Publication Details
- Neural regeneration research, v 11(9), pp 1365-1367
- Publisher
- Wolters Kluwer Medknow Publications
- Number of pages
- 3
- Grant note
- R01-NS041596; R01-NS089663; P01-NS055976 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 2011329 / US-Israel Binational Science Foundation Dr. Miriam and Sheldon G. Adelson Medical Research Foundation R01NS041596 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) W81XWH-13-1-0308 / Department of Defense/Congressionally Mandated Research Program MCB-1020970 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000387768400001
- Scopus ID
- 2-s2.0-84994850706
- Other Identifier
- 991019168739004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Neurosciences