Journal article
Intracisternal rSV40 administration provides effective pan-CNS transgene expression
Gene therapy, v 19(1), pp 114-118
01 Jan 2012
PMID: 21614027
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Potential genetic treatments for many generalized central nervous system (CNS) diseases require transgene expression throughout the CNS. Using oxidant stress and apoptosis caused by HIV-1 envelope gp120 as a model, we studied pan-CNS neuroprotective gene delivery into the cisterna magna (CM). Recombinant SV40 vectors carrying Cu/Zn superoxide dismutase or glutathione peroxidase were injected into rat CMs following intraperitoneal administration of mannitol. Sustained transgene expression was seen in neurons throughout the CNS. On challenge, 8 weeks later with gp120 injected into the caudate putamen, significant neuroprotection was documented. Thus, intracisternal administration of antioxidant-carrying rSV40 vectors may be useful in treating widespread CNS diseases such as HIV-1-associated neurocognitive disorders characterized by oxidative stress. Gene Therapy (2012) 19, 114-118; doi:10.1038/gt.2011.75; published online 26 May 2011
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Details
- Title
- Intracisternal rSV40 administration provides effective pan-CNS transgene expression
- Creators
- J-P Louboutin - Thomas Jefferson UniversityB. A. S. Reyes - Thomas Jefferson UniversityL. Agrawal - Thomas Jefferson UniversityE. J. Van Bockstaele - Thomas Jefferson UniversityD. S. Strayer - Thomas Jefferson University
- Publication Details
- Gene therapy, v 19(1), pp 114-118
- Publisher
- Springer Nature
- Number of pages
- 5
- Grant note
- MH69122; MH70287 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01MH070287 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000299049000014
- Scopus ID
- 2-s2.0-84855421063
- Other Identifier
- 991021903411304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biotechnology & Applied Microbiology
- Genetics & Heredity
- Medicine, Research & Experimental