Journal article
Intracoronary thrombus in nontransmural myocardial infarction and in unstable angina pectoris
The American journal of cardiology, v 52(1), pp 1-6
1983
PMID: 6407296
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although intracoronary thrombus formation plays a major role in acute transmural myocardial infarction (MI), its occurrence in unstable angina (UA) and nontransmural MI has not clearly been established. To determine whether intracoronary thrombus does occur in these syndromes, coronary arteriography was performed before, during, and after intracoronary nitroglycerin and streptokinase infusion in 17 patients. None of the 8 patients with nontransmural MI and 1 of the 9 patients with UA responded to intracoronary nitroglycerin. Seven of 8 patients with nontransmural MI and 4 of 9 patients with UA responded to streptokinase infusion with opening of an occluded vessel, an increase in stenotic diameter, dissolution of an intracoronary filling defect, or a combination of these. Serial opening and closing of ischemia-related vessels occurred spontaneously and in response to streptokinase in some patients in whom thrombolysis was demonstrated. Evidence of thrombolysis was not seen in any patient studied longer than 1 week from the onset of the rest pain syndrome.
The finding of thrombolysis in several patients with nontransmural MI and UA suggests that intracoronary thrombus formation plays a pathogenetic role in some patients with these ischemic syndromes.
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Details
- Title
- Intracoronary thrombus in nontransmural myocardial infarction and in unstable angina pectoris
- Creators
- Jay B. Mandelkorn - Drexel UniversityNelson M. Wolf - Drexel UniversitySurender Singh - Drexel UniversityJay A. Shechter - Drexel UniversityRobert I. Kersh - Drexel UniversityDavid M. Rodgers - Drexel UniversityMark B. Workman - Drexel UniversityLamberto G. Bentivoglio - Drexel UniversitySteven M. LaPorte - Drexel UniversitySteven G. Meister - Drexel UniversitySabina B Singh - Pediatrics
- Publication Details
- The American journal of cardiology, v 52(1), pp 1-6
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1983QX24200002
- Scopus ID
- 2-s2.0-0020606828
- Other Identifier
- 991019184093904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems