Journal article
Intracortical Remodeling Parameters are Associated with Measures of Bone Robustness
Anatomical record (Hoboken, N.J. : 2007), v 297(10), pp 1817-1828
01 Oct 2014
PMID: 24962664
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue-level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU-based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38% and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e. g., % secondary tissue [R-2 - 0.68, P<0.004], total osteon area [R-2 - 0.42, P<0.04]) at the 66% site. Although these associations were weaker at the 38% site, significant correlations between histological variables were identified between the two sites indicating that both respond to the same global effects and demonstrate a similar character at the whole bone level. Thus, robust bones tended to have larger and more numerous osteons with less infilling, resulting in bigger pores and more secondary bone area. These results suggest that local regulation of BMU-based remodeling may be further modulated by a global signal associated with robustness, such that remodeling is suppressed in slender bones but not in robust bones. Elucidating this mechanism further is crucial for better understanding the complex adaptive nature of the skeleton, and how interindividual variation in remodeling differentially impacts skeletal aging and an individuals' potential response to prophylactic treatments. (C) 2014 Wiley Periodicals, Inc.
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Details
- Title
- Intracortical Remodeling Parameters are Associated with Measures of Bone Robustness
- Creators
- Haviva M. Goldman - Drexel UniversityNaomi A. Hampson - Drexel UniversityJ. Jared Guth - Drexel UniversityDavid Lin - Drexel UniversityKarl J. Jepsen - University of Michigan–Ann Arbor
- Publication Details
- Anatomical record (Hoboken, N.J. : 2007), v 297(10), pp 1817-1828
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- (DoD) W81XWH-09-2-0113; W81XWH-07-C-0097 / US Department of Defense; United States Department of Defense R01AR065424 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) AR44927 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000342342100004
- Scopus ID
- 2-s2.0-84907878759
- Other Identifier
- 991019169001204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Anatomy & Morphology