Journal article
Intracranial Electroencephalography Reveals Selective Responses to Cognitive Stimuli in the Periventricular Heterotopias
The Journal of neuroscience, v 41(17), pp 3870-3878
28 Apr 2021
PMID: 33727335
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Our recent work suggests that non-lesional epileptic brain tissue is capable of generating normal neurophysiological responses during cognitive tasks, which are then seized by ongoing pathologic epileptic activity. Here, we aim to extend the scope of our work to epileptic periventricular heterotopias (PVH) and examine whether the PVH tissue also exhibits normal neurophysiological responses and network-level integration with other non-lesional cortical regions. As part of routine clinical assessment, three adult patients with PVH underwent implantation of intracranial electrodes and participated in experimental cognitive tasks. We obtained simultaneous recordings from PVH and remote cortical sites during rest as well as controlled experimental conditions. In all three subjects (two females), cognitive experimental conditions evoked significant electrophysiological responses in discrete locations within the PVH tissue that were correlated with responses seen in non-epileptic cortical sites. Moreover, the responsive PVH sites exhibited correlated electrophysiological activity with responsive, non-lesional cortical sites during rest conditions. Taken together, our work clearly demonstrates that the PVH tissue may be functionally organized and it may be functionally integrated within cognitively engaged cortical networks despite its anatomic displacement during neurodevelopment.
Periventricular heterotopias (PVH) are developmentally abnormal brain tissues that frequently cause epileptic seizures. In a rare opportunity to obtain direct electrophysiological recordings from PVH, we were able to show that, contrary to common assumptions, PVH functional activity is similar to healthy cortical sites during a well-established cognitive task and exhibits clear resting state connectivity with the responsive cortical regions.
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Details
- Title
- Intracranial Electroencephalography Reveals Selective Responses to Cognitive Stimuli in the Periventricular Heterotopias
- Creators
- Serdar Akkol - Stanford UniversityAaron Kucyi - Stanford UniversityWenhan Hu - Beijing Tian Tan HospitalBaotian Zhao - Beijing Tian Tan HospitalChao Zhang - Beijing Tian Tan HospitalClara Sava-Segal - Stanford UniversitySu Liu - Stanford UniversityBabak Razavi - Stanford UniversityJianguo Zhang - Beijing Tian Tan HospitalKai Zhang - Beijing Tian Tan HospitalJosef Parvizi - Stanford University
- Publication Details
- The Journal of neuroscience, v 41(17), pp 3870-3878
- Publisher
- Society for Neuroscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000694859000010
- Scopus ID
- 2-s2.0-85105835313
- Other Identifier
- 991021448152104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences