Journal article
Intralimb and Interlimb Cutaneous Reflexes during Locomotion in the Intact Cat
The Journal of neuroscience, v 38(17), pp 4104-4122
25 Apr 2018
PMID: 29563181
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
When the foot contacts an obstacle during locomotion, cutaneous inputs activate spinal circuits to ensure dynamic balance and forward progression. In quadrupeds, this requires coordinated reflex responses between the four limbs. Here, we investigated the patterns and phasic modulation of cutaneous reflexes in forelimb and hindlimb muscles evoked by inputs from all four limbs. Five female cats were implanted to record muscle activity and to stimulate the superficial peroneal and superficial radial nerves during locomotion. Stimulating these nerves evoked short-, mid-, and longer-latency excitatory and/or inhibitory responses in all four limbs that were phase-dependent. The largest responses were generally observed during the peak activity of the muscle. Cutaneous reflexes during mid-swing were consistent with flexion of the homonymous limb and accompanied by modification of the stance phases of the other three limbs, by coactivating flexors and extensors and/or by delaying push-off. Cutaneous reflexes during mid-stance were consistent with stabilizing the homonymous limb by delaying and then facilitating its push-off and modifying the support phases of the homolateral and diagonal limbs, characterized by coactivating flexors and extensors, reinforcing extensor activity and/or delaying push-off. The shortest latencies of homolateral and diagonal responses were consistent with fast-conducting disynaptic or trisynaptic pathways. Descending homolateral and diagonal pathways from the forelimbs to the hindlimbs had a higher probability of eliciting responses compared with ascending pathways from the hindlimbs to the forelimbs. Thus, in quadrupeds, intralimb and interlimb reflexes activated by cutaneous inputs ensure dynamic coordination of the four limbs, producing a whole-body response.
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Details
- Title
- Intralimb and Interlimb Cutaneous Reflexes during Locomotion in the Intact Cat
- Creators
- Marie-France Hurteau - Université de SherbrookeYann Thibaudier - Université de SherbrookeCharline Dambreville - Université de SherbrookeSimon M. Danner - Drexel UniversityIlya A. Rybak - Drexel UniversityAlain Frigon - Université de Sherbrooke
- Publication Details
- The Journal of neuroscience, v 38(17), pp 4104-4122
- Publisher
- Soc Neuroscience
- Number of pages
- 19
- Grant note
- R01NS090919 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) RGPIN-2016-03790 / Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada (NSERC); CGIAR Arthur C. Guyton Award for Excellence in Integrative Physiology American Physiological Society R01 NS090919 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Natural Sciences and Engineering Research Council of Canada; Natural Sciences and Engineering Research Council of Canada (NSERC); CGIAR 182035 / Fonds de Recherche du Quebec-Natures et Technologies
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000431123900006
- Scopus ID
- 2-s2.0-85050904282
- Other Identifier
- 991019167658404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences