Journal article
Intramuscular Botulinum Toxin A (BtxA) in Complex Regional Pain Syndrome
Pain physician, v 14(3), pp 311-316
01 May 2011
PMID: 21587336
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Pain associated with complex regional pain syndrome (CRPS) is frequently excruciating and intractable. The use of botulinum toxin for relief of CRPS-associated pain has not been well described.
Objectives: To assess whether intramuscular botulinum toxin injections cause relief of pain caused by CRPS, and to assess the risks of this treatment.
Study Design: Retrospective chart review.
Setting: Outpatient clinic.
Methods: Patients: 37 patients with spasm/dystonia in the neck and/or upper limb girdle muscles. Intervention: Electromyography-guided injection of botulinum toxin A (BtxA), 10-20 U per muscle. Total dose used was 100 U in each patient. Measurement: Local pain score on an 11 point Likert scale, 4 weeks after BtxA injections.
Results: Mean pain score decreased by 43% (8.2 +/- 0.8 to 4.5 +/- 1.1, P < 0.001). Ninety-seven percent of the patients had significant pain relief. One patient had transient neck drop after the injections.
Limitations: This is a retrospective study; it lacks a control group and therefore the placebo effect cannot be eliminated. This study does not provide information on the efficacy of this treatment after 4 weeks.
Conclusion(s): Intramuscular injection of botulinum toxin A in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS in this retrospective case series. The incidence of complications was low (2.7%)
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Details
- Title
- Intramuscular Botulinum Toxin A (BtxA) in Complex Regional Pain Syndrome
- Creators
- Siddharth Kharkar - Hahnemann University HospitalPrakash Ambady - Drexel UniversityVenkatesh Yedatore - Drexel UniversityRobert Schwartzman - Drexel University
- Publication Details
- Pain physician, v 14(3), pp 311-316
- Publisher
- Am Soc Interventional Pain Physicians
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000295613300012
- Scopus ID
- 2-s2.0-79957799823
- Other Identifier
- 991019168086304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Anesthesiology
- Clinical Neurology