Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model
Scientific reports, v 7(1), 41768
31 Jan 2017
PMID: 28139754
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental autoimmune encephalomyelitis animal model of multiple sclerosis was assessed. Currently, there are no existing optic nerve treatment methods for disease or trauma that result in permanent vision loss. Demyelinating optic nerve inflammation, termed optic neuritis, induces permanent visual dysfunction due to retinal ganglion cell damage in multiple sclerosis and experimental autoimmune encephalomyelitis. ST266, the biological secretome of Amnion-derived Multipotent Progenitor cells, contains multiple anti-inflammatory cytokines and growth factors. Intranasally administered ST266 accumulated in rodent eyes and optic nerves, attenuated visual dysfunction, and prevented retinal ganglion cell loss in experimental optic neuritis, with reduced inflammation and demyelination. Additionally, ST266 reduced retinal ganglion cell death in vitro. Neuroprotective effects involved oxidative stress reduction, SIRT1-mediated mitochondrial function promotion, and pAKT signaling. Intranasal delivery of neuroprotective ST266 is a potential novel, noninvasive therapeutic modality for the eyes, optic nerves and brain. The unique combination of biologic molecules in ST266 provides an innovative approach with broad implications for suppressing inflammation in autoimmune diseases, and for preventing neuronal damage in acute neuronal injury and chronic neurodegenerative diseases such as multiple sclerosis.
Metrics
Details
- Title
- Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model
- Creators
- Reas S Khan - Penn Presbyterian Medical CenterKimberly Dine - Penn Presbyterian Medical CenterBailey Bauman - University of PennsylvaniaMichael Lorentsen - Drexel UniversityLisa Lin - University of PennsylvaniaHelayna Brown - Drexel UniversityLeah R Hanson - HealthPartnersAleta L Svitak - HealthPartnersHoward Wessel - Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, USALarry Brown - Noveome Biotherapeutics, Inc., Pittsburgh, Pennsylvania, USAKenneth S Shindler - Penn Presbyterian Medical Center
- Publication Details
- Scientific reports, v 7(1), 41768
- Publisher
- Springer Nature
- Number of pages
- 12
- Grant note
- R43 EY015014 / NEI NIH HHS R01 EY019014 / NEI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000393080500001
- Scopus ID
- 2-s2.0-85011299132
- Other Identifier
- 991021876910704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences