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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Intraocular Pressure and Central Corneal Thickness in the COMET Cohort
Optometry and vision science, v 89(8), pp 1225-1234
01 Aug 2012
PMID: 22820476
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Abstract
Purpose. To describe intraocular pressure (IOP) and central corneal thickness (CCT) in ethnically diverse, myopic young adults enrolled in COMET (the Correction of Myopia Evaluation Trial) and their association with ocular and demographic factors.
Methods. IOP (Goldmann tonometry), CCT (handheld pachymetry), refractive error (cycloplegic autorefraction), and ocular components (A-scan ultrasonography) were measured in 385 of the original 469 subjects (mean age = 20.3 +/- 1.3 years). Summary statistics for descriptive analysis, Pearson correlation coefficients, and linear regression models to formally test the association of IOP and CCT with other covariates were used.
Results. Mean IOP was 15.1 +/- 0.1 mm Hg and differed by ethnicity and CCT but did not vary by gender, magnitude of myopia, or vitreous chamber depth (VCD). Adjusting for CCT, IOP in black participants was 1.8 mm Hg higher than in Hispanics (p = 0.0001) and 0.8 mm Hg higher than in whites (p = 0.03). Mean CCT was 562.4 +/- 1.8 mu m and differed by ethnicity, VCD, and IOP after adjusting for covariates. Blacks had thinner corneas than Asians, whites, and Hispanics, with adjusted differences of 15.4, 11.8, and 15.3 mu m (p = 0.03, < 0.01 and < 0.01), respectively. Eyes with shorter VCD (< 17.8 mm) had 8.0-mu m thinner CCT (p = 0.03). CCT did not vary by gender or magnitude of myopia. Overall, a modest positive correlation (r = 0.25, P < 0.0001) was found between IOP and CCT, which varied by ethnicity in Asians (r = 0.47; p = 0.008), blacks (r = 0.29; p = 0.002), and whites (r = 0.24; p = 0.002).
Conclusions. Myopic, black young adults had higher IOP and thinner corneas relative to other ethnic groups, suggesting that evaluation of these parameters during routine examination of these individuals should begin at a young age. Their thinner CCT should also be considered in evaluations for refractive surgery. (Optom Vis Sci 2012;89:1225-1234)
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Details
- Title
- Intraocular Pressure and Central Corneal Thickness in the COMET Cohort
- Creators
- Karen D. Fern - University of HoustonRuth E. Manny - University of HoustonJane Gwiazda - New England College of OptometryLeslie Hyman - New England College of OptometryKatherine Weise - New England College of OptometryWendy Marsh-Tootle - University of AlabamaCOMET Study GrpMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Optometry and vision science, v 89(8), pp 1225-1234
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- EY11756; EY11754; EY11805; EY11752; EY11740; EY11755 / National Eye Institute, National Institute of Health, NEI/NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10EY011752 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000307476600018
- Scopus ID
- 2-s2.0-84864666035
- Other Identifier
- 991021900613204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology