Journal article
Intraperitoneal immunotherapy: historical perspectives and modern therapy
Cancer gene therapy, v 23(11), pp 373-381
Nov 2016
PMID: 27834358
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intraperitoneal immunotherapy represents a novel strategy for the management of peritoneal metastases (PM). Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has remained the gold standard of treatment for patients with PM, yet despite optimal treatment, recurrence rates remain high and long-term survival poor. From Coley's toxins to immune checkpoint inhibitors, the wide variety of anticancer immunotherapeutic strategies are now garnering attention for control of regional disease of the peritoneal cavity. Early studies with vaccine-based therapies, adoptive cell transfer, immune checkpoint inhibitors, and chimeric T cells with tumor-specific antigen receptors (CAR-T cells) are being performed, showing promise for control of peritoneal spread and induction of lasting anticancer immunity. In addition, catumaxomab, a trifunctional antibody, has been approved for intraperitoneal immunotherapy in Europe for the control of malignant ascites in patients with epithelial cell adhesion molecule positive cancers. We review a brief history of immunotherapy and current modalities under investigation for intraperitoneal use in the treatment of PM.
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Details
- Title
- Intraperitoneal immunotherapy: historical perspectives and modern therapy
- Creators
- W F Morano - Drexel UniversityA Aggarwal - Drexel UniversityP Love - Drexel UniversityS D Richard - Drexel UniversityJ Esquivel - Department of Surgery, Frederick Memorial Hospital, Frederick, MD, USA.W B Bowne - Drexel University
- Publication Details
- Cancer gene therapy, v 23(11), pp 373-381
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Obstetrics and Gynecology
- Web of Science ID
- WOS:000388063700002
- Scopus ID
- 2-s2.0-84994792226
- Other Identifier
- 991019168003304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Genetics & Heredity
- Medicine, Research & Experimental
- Oncology