Journal article
Intraprostatic calcification and biochemical recurrence in men treated with cesium-131 prostate brachytherapy
Brachytherapy, v 20(4), pp 859-865
01 Jul 2021
PMID: 33994343
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Baseline intraprostatic calcification (IC) has been shown to be associated with a higher rate of biochemical recurrence (BCR) in men treated with iodine-125 prostate brachytherapy (PB). We evaluated this association in a cohort of men treated with cesium-131 PB.
We retrospectively reviewed the charts of all low- and intermediate-risk prostate cancer patients treated with cesium-131 PB +/- external beam radiotherapy (EBRT) at our institution from 2/2011 to 7/2018. Patients with < 24 months of follow up or those who received androgen deprivation therapy were excluded. Baseline IC status (defined as one or more ICs ≥ 5 mm) was determined on post-PB CT scans. Cox analysis was used to assess predictors of BCR and Kaplan–Meier survival curves were calculated.
Two hundred and sixteen low- and intermediate-risk prostate cancer patients treated with cesium-131 PB +/- EBRT were included. Median follow up was 56.9 months (range 24.1–111.4). Overall, 76 (35.2%) patients had baseline IC and 140 (64.8%) did not. Baseline disease characteristics did not differ significantly between groups. On univariate Cox analysis, only risk group (p = 0.047) and initial PSA (p = 0.016) were significant predictors of BCR, whereas baseline IC was not (p = 0.11). The 5-year BCR-free survival in patients with versus without baseline IC was 97.7% versus 93.8% (p = 0.405), respectively.
In a cohort of low- and intermediate-risk prostate cancer patients treated with cesium-131 PB, the rate of BCR in men with baseline IC was low and baseline IC was not associated with a higher risk of BCR.
Metrics
Details
- Title
- Intraprostatic calcification and biochemical recurrence in men treated with cesium-131 prostate brachytherapy
- Creators
- Michael D. Schad - University of PittsburghJoshua L. Rodríguez-López - University of Pittsburgh School of MedicineAnkur K. Patel - UPMC Hillman Cancer CenterChristopher J. Houser - UPMC Hillman Cancer CenterZachary D. Horne - Allegheny Health NetworkRonald M. Benoit - University of Pittsburgh School of MedicineRyan P. Smith - UPMC Hillman Cancer CenterSushil Beriwal - UPMC Hillman Cancer Center
- Publication Details
- Brachytherapy, v 20(4), pp 859-865
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000669646300019
- Scopus ID
- 2-s2.0-85106323253
- Other Identifier
- 991021897265304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging