Journal article
Intrathecal baclofen overdose followed by withdrawal: clinical and EEG features
Pediatric neurology, v 33(5), pp 373-377
Nov 2005
PMID: 16243227
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intrathecal baclofen therapy is increasingly used to alleviate medically intractable spasticity in children with cerebral palsy, spinal cord injuries, and generalized dystonia. Complications like overdose or withdrawal can occur and could be the result of pump malfunction (device-related) or refilling and programming mistakes (human errors). This report describes a case, with emphasis on electroencephalographic changes, of a 12-year old male on long-term intrathecal baclofen therapy who had sequential occurrence of both acute inadvertent baclofen overdose followed by withdrawal symptoms. During baclofen intoxication, electroencephalography documented periodic generalized epileptiform discharges, occasionally followed by intermittent electro-decremental responses on a background of diffuse delta slowing (1-2 Hz). During withdrawal, mild generalized slowing during wakefulness was observed along with the appearance of high-amplitude, sharply contoured delta activity resembling frontal intermittent rhythmic delta activity in sleep. To our knowledge, this temporal profile of electroencephalographic features during baclofen intoxication followed by withdrawal has not been described before in pediatric patients. It is important for treating physicians to recognize the evolution of this electroencephalographic pattern in order to avoid misinterpretation of diagnosis and prognosis.
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Details
- Title
- Intrathecal baclofen overdose followed by withdrawal: clinical and EEG features
- Creators
- Farzana P Darbari - St. Christopher's Hospital for ChildrenJoseph J Melvin - St. Christopher's Hospital for ChildrenJoseph H Piatt, JrTerry A Adirim - St. Christopher's Hospital for ChildrenSanjeev V Kothare - St. Christopher's Hospital for Children
- Publication Details
- Pediatric neurology, v 33(5), pp 373-377
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000233846900012
- Scopus ID
- 2-s2.0-27144553118
- Other Identifier
- 991019168809304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics