Journal article
Intravenous Immunoglobulin Prophylaxis of Cytomegalovirus Infection in Pediatric Renal Transplant Recipients
American journal of nephrology, v 17(2), pp 146-152
1997
PMID: 9096445
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cytomegalovirus (CMV), the most significant infectious cause of morbidity following renal transplantation, may be a greater problem for children than for adults due to their relative lack of experience with this virus. Therefore, we prospectively gave Gammagard® as prophylaxis to CMV-negative children who received CMV-positive allografts and compared the results to our experience with similar high-risk recipients transplanted prior to our use of intravenous immunoglobulin G (IvIgG). Symptomatic CMV disease developed in 17% of the IvIgG recipients as compared with 71% of the untreated patients (p = 0.01). The CMV infections that did occur in IvIgG recipients developed significantly later than in untreated children (median time of onset after transplantation 2.60 vs. 1.35 months; p < 0.05) and generally were less severe, although 1 IvIgG recipient died despite prophylaxis. IvIgG administration did not affect the frequency of rejection or graft or patient survival. We conclude that IvIgG administration to high-risk pediatric renal transplant recipients may protect against posttransplantation CMV disease and may lessen the severity of infections that do develop in patients who receive it.
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Details
- Title
- Intravenous Immunoglobulin Prophylaxis of Cytomegalovirus Infection in Pediatric Renal Transplant Recipients
- Creators
- Joseph T Flynn - St. Christopher's Hospital for ChildrenBruce A KaiserSarah S LongSeth L SchulmanAdamadia DeforestMartin S PolinskyJorge Baluarte
- Publication Details
- American journal of nephrology, v 17(2), pp 146-152
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1997WR10000007
- Scopus ID
- 2-s2.0-0030933657
- Other Identifier
- 991019335216404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Urology & Nephrology