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Intravenous infusions of nitroprusside, dobutamine, and nitroglycerin are compatible
Journal article   Peer reviewed

Intravenous infusions of nitroprusside, dobutamine, and nitroglycerin are compatible

JAN Horrow, G Digregorio, EDWARD Barbieri, ELLEN Rupp and Jay C Horrow
Critical care medicine, v 18(8), pp 858-861
Aug 1990
DOI: https://doi.org/10.1097/00003246-199008000-00013
PMID: 2116261
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

It is now customary practice to couple separately metered infusions via a manifold to a common catheter that enters the patient. Nitroprusside, however, is considered incompatible with all other medications. Critically ill patients who require multiple infusions of vasoactive and inotropic medications would benefit if physicians had additional information regarding compatibility of nitroprusside with other commonly used infusions. Utilizing high-performance liquid chromatography, the authors investigated the physical and chemical compatibility of nitroprusside, dobutamine, and nitroglycerin in solutions of 5% dextrose or 0.9% NaCl at clinically relevant concentrations. AH drugs were present within the guidelines of the U.S. Pharmacopeia (±10%) over 24 h in NaCl, but nitroglycerin degraded over 24 h when the three drugs were mixed in dextrose. We recommend diluting these medicines in NaCl when mixtures of them would exist for ≥ h.

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6 citations in Web of Science
5 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being
#2 Zero Hunger

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Web of Science research areas
Critical Care Medicine
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