Journal article
Intravenous levetiracetam in children with epilepsy
Pediatric neurology, v 38(3), pp 177-180
01 Mar 2008
PMID: 18279751
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intravenous levetiracetam recently became available for use in patients aged > 16 years. There are few data about its safety and efficacy in children. We retrospectively analyzed data from children treated with intravenous levetiracetam. Ten patients (6 female, 4 male), aged 3 weeks to 19 years, were treated with intravenous levetiracetam at a mean dose of 50.5 mg/kg/day for a mean duration of 4.9 days. Four patients received intravenous levetiracetam for acute repetitive seizures/status epilepticus, and three as replacement for oral levetiracetam because administration of oral levetiracetam was temporarily infeasible. One patient each received intravenous levetiracetam for seizure prophylaxis during brain biopsy, as maintenance treatment after acute seizures, and as substitute for sodium valproate. Three of four patients with acute repetitive seizures/status epilepticus became seizure-free; the fourth patient had a partial reduction in seizure frequency. All three patients who received intravenous levetiracetam as substitute for oral levetiracetam tolerated the switch well. The other three patients were seizure-free on intravenous levetiracetam. No serious adverse effects were observed, and all patients completed treatment with intravenous levetiracetam for the intended period. Intravenous levetiracetam may be effective in various clinical situations requiring intravenous administration of an antiepileptic drug. (C) 2008 by Elsevier Inc. All rights reserved.
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Details
- Title
- Intravenous levetiracetam in children with epilepsy
- Creators
- Jatinder S. Goraya - St. Christopher's Hospital for ChildrenDivya S. Khurana - St. Christopher's Hospital for ChildrenIgnacio Valencia - St. Christopher's Hospital for ChildrenJoseph J. Melvin - St. Christopher's Hospital for ChildrenMarcos Cruz - St. Christopher's Hospital for ChildrenAgustin Legido - St. Christopher's Hospital for ChildrenSanjeev V. Kothare - St. Christopher's Hospital for Children
- Publication Details
- Pediatric neurology, v 38(3), pp 177-180
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000253446600003
- Scopus ID
- 2-s2.0-38949184571
- Other Identifier
- 991019168786704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Pediatrics