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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Investigating the Efficacy of Subharmonic Aided Pressure Estimation for Portal Vein Pressures and Portal Hypertension Monitoring
Ultrasound in medicine & biology, v 38(10), pp 1784-1798
Oct 2012
PMID: 22920550
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The efficacy of using subharmonic emissions from Sonazoid microbubbles (GE Healthcare, Oslo, Norway) to track portal vein pressures and pressure changes was investigated in 14 canines using either slow- or high-flow models of portal hypertension (PH). A modified Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA) operating in subharmonic mode (ftransmit: 2.5 MHz, freceive: 1.25 MHz) was used to collect radiofrequency data at 10–40% incident acoustic power levels with 2–4 transmit cycles (in triplicate) before and after inducing PH. A pressure catheter (Millar Instruments, Inc., Houston, TX, USA) provided reference portal vein pressures. At optimum insonification, subharmonic signal amplitude changes correlated with portal vein pressure changes; r ranged from −0.82 to −0.94 and from −0.70 to −0.73 for PH models considered separately or together, respectively. The subharmonic signal amplitudes correlated with absolute portal vein pressures (r: −0.71 to −0.79). Statistically significant differences between subharmonic amplitudes, before and after inducing PH, were noted (p ≤ 0.01). Portal vein pressures estimated using subharmonic aided pressure estimation did not reveal significant differences (p > 0.05) with respect to the pressures obtained using the Millar pressure catheter. Subharmonic-aided pressure estimation may be useful clinically for portal vein pressure monitoring.
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Details
- Title
- Investigating the Efficacy of Subharmonic Aided Pressure Estimation for Portal Vein Pressures and Portal Hypertension Monitoring
- Creators
- Jaydev K. Dave - Thomas Jefferson UniversityValgerdur G. Halldorsdottir - Thomas Jefferson UniversityJohn R. Eisenbrey - Thomas Jefferson UniversityDaniel A. Merton - Thomas Jefferson UniversityJi-Bin Liu - Thomas Jefferson UniversityJian-Hua Zhou - Thomas Jefferson UniversityHsin-Kai Wang - Thomas Jefferson UniversitySuhyun Park - GE Global Research (United States)Scott Dianis - GE Global Research (United States)Carl L. Chalek - GE Global Research (United States)Feng Lin - GE Global Research (United States)Kai E. Thomenius - GE Global Research (United States)Daniel B. Brown - Thomas Jefferson UniversityFlemming Forsberg - Thomas Jefferson University
- Publication Details
- Ultrasound in medicine & biology, v 38(10), pp 1784-1798
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000308543800012
- Scopus ID
- 2-s2.0-84865761072
- Other Identifier
- 991019350588004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging