Journal article
Investigating the Usage of Abiraterone in African American Men with Metastatic Prostate Cancer
Journal of racial and ethnic health disparities
24 Jun 2025
PMID: 40553297
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
African American men bear an unequal proportion of metastatic prostate cancer burden. The utilization of second-generation anti-androgens like abiraterone with androgen deprivation therapy (ADT) has become a standard therapy for metastatic prostate cancer. Thus, we aimed to examine the utilization of abiraterone with ADT in African American men with metastatic disease and determine whether disparities in its use exist.
This is a retrospective study, using a multi-institutional regional collaborative prostate cancer database. We compared the use of ADT with abiraterone between African American men and non-African American men diagnosed with distantly metastatic prostate cancer from July 2015 to August 2022, using logistic regression and negative binomial regression.
We identified 201 men with metastatic prostate cancer and of those, 28% were African American men. African American men were younger (47% vs. 27.8%, ≤ 69 years, p = 0.002), and younger men experienced a longer time between diagnosis of metastatic disease and receipt of ADT with abiraterone compared to older men (mean 125 vs. 14 days, p = 0.038). While African American and non-African American men had similar rates of ADT use with abiraterone, African American men experienced longer times between documented metastatic disease and initiation of ADT with abiraterone (mean 187 vs. 79 days, p = 0.042).
The initiation of ADT with abiraterone was delayed by 3 months in African American men. This discrepancy warrants an investigation of system level barriers to the timely initiation of abiraterone in African American men given its known oncologic benefits.
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Details
- Title
- Investigating the Usage of Abiraterone in African American Men with Metastatic Prostate Cancer
- Creators
- Christine Ibilibor - University of VirginiaMarieke Jones - University of VirginiaJeffrey Tomaszewski - Cooper University Health CareSerge Ginzburg - Einstein Healthcare NetworkAndres Correa - Fox Chase Cancer CenterRobert Uzzo - Fox Chase Cancer CenterMarc Smaldone - Fox Chase Cancer CenterJohn Danella - Geisinger Health SystemThomas J Guzzo - University of PennsylvaniaDaniel Lee - University of PennsylvaniaLaurence Belkoff - Main Line HealthJeffrey Walker - Main Line HealthJay D Raman - Pennsylvania State UniversityAdam Reese - Temple UniversityMihir S Shah - Thomas Jefferson University HospitalBruce Jacobs - University of PittsburghThomas Jang - Rutgers, The State University of New JerseyKeith Kowalczyk - MedStar Georgetown University HospitalMeghan Smith - Health Care Improvement Foundation, Philadelphia, PA, USA
- Publication Details
- Journal of racial and ethnic health disparities
- Publisher
- SPRINGER INT PUBL AG; CHAM
- Number of pages
- 8
- Grant note
- Health Care Improvement Foundation
Data were provided with permission from the Pennsylvania Urologic Regional Collaborative (PURC) participating urology practices. PURC is a quality improvement initiative led by the Health Care Improvement Foundation which brings urology practices together in a physician-led, data-sharing and improvement collaborative aimed at advancing the quality of diagnosis and care for men with prostate cancer.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:001514295800001
- Scopus ID
- 2-s2.0-105008913765
- Other Identifier
- 991022059740304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health