Journal article
Investigating the role of nitric oxide in regulating blood flow and oxygen delivery from in vivo electrochemical measurements in eye and brain
Advances in experimental medicine and biology, v 530, pp 359-370
01 Jan 2003
PMID: 14562731
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have previously shown from direct, in vivo measurements of NO in cats with recessed electrochemical microsensors that NO mediates increases in ONH blood flow during functional activation of the eye by flickering light. We have also reported that there are low frequency (< 15 cycles/min) spontaneous oscillations in NO that appear to be passively coupled to oscillations in blood flow at similar frequencies in the cat ONH. In this paper, we describe similarities between in vivo measurements of NO in the ONH of the cat eye and in the cortex of the rat brain. These data are consistent with a role for NO in the coupling of blood flow with increases in neuronal activity, autoregulation of blood flow, hyperemia, and vasodilation during hypoxia and hypercapnia.
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Details
- Title
- Investigating the role of nitric oxide in regulating blood flow and oxygen delivery from in vivo electrochemical measurements in eye and brain
- Creators
- Donald G Buerk - University of PennsylvaniaDmitriy N Atochin - University of PennsylvaniaCharles E Riva - Institut de Recherches en Ophthalmologie
- Publication Details
- Advances in experimental medicine and biology, v 530, pp 359-370
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000186182800033
- Scopus ID
- 2-s2.0-0242362068
- Other Identifier
- 9781461500759; 1461500753; 991019231738804721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Physiology