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Investigating the spatial extent of acoustically activated echogenic liposomes
Journal article   Open access   Peer reviewed

Investigating the spatial extent of acoustically activated echogenic liposomes

An T. Nguyen, Youhan Sunny, Christopher Bawiec, Peter A. Lewin and Steven P. Wrenn
Ultrasonics, v 77, pp 176-182
May 2017
DOI: https://doi.org/10.1016/j.ultras.2017.01.022
PMID: 28246036
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.ultras.2017.01.022View
Accepted (AM)Open Access (Publisher-Specific),  Open

Abstract

Cavitation Controlled release Echogenic Liposomes Ultrasound
• Increased calcein release due to echogenicity is strictly a localized event. • Release mechanisms due to echogenicity were active during the initial 1–2min. • Effect of echogenicity on leakage overshadowed the effect of lipid phase. The purpose of this work was to investigate the ability of bubbles entrapped within echogenic liposomes (ELIP) to serve as foci for cavitational events that would cause leakage in neighboring non-echogenic liposomes (NELIP). Previous studies have shown that entrapping bubbles into liposomes increases ultrasound-mediated leakage of hydrophilic components at ultrasound settings known to induce inertial cavitation, specifically 20kHz and 2.2W/cm2. Using tone-burst approach and pulse repetition frequency of 10Hz would bring this intensity level to the one accepted (220mW/cm2) in clinical imaging. Mixed populations of ELIP and NELIP were simultaneously exposed to ultrasound at varying ratios to examine the effect of ELIP concentration on release of a hydrophilic dye, calcein, from NELIP. Calcein release from NELIP was observed to be independent of ELIP concentration, suggesting that the release enhancement from echogenicity is strictly a localized event. Additionally, it was observed that the release mechanisms independent of echogenicity were active for the duration of experiment whereas those associated with echogenicity were active for only the initial 1–2min.

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Web of Science research areas
Acoustics
Radiology, Nuclear Medicine & Medical Imaging
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