Journal article
Investigating thyroid dysfunction in the context of COVID-19 infection
Annals of medicine and surgery, v 84, pp 104806-104806
01 Dec 2022
PMID: 36339111
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
COVID-19 is a contagious viral infection caused by severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2). One of the key features of COVID-19 infection is inflammation. There is increasing evidence pointing to an association between cytokine storm and autoimmunity. One autoimmune disease of interest in connection to COVID-19 is hyperthyroidism. COVID-19 has been shown to decrease TSH levels and induce thyrotoxicosis, destructive thyroiditis, and de novo Graves' disease. It has also been suggested that the immune response against SARS-CoV-2 antigens following vaccination can cross-react through a mechanism called molecular mimicry which can elicit autoimmune reactivity, potentially leading to potential thyroid disease post vaccine. However, if the COVID-19 vaccine is linked to reduced COVID-19 related serious disease, it could potentially play a protective role against post COVID-19 hyperthyroidism (de novo disease and exacerbations). Further studies investigating the complex interplay between COVID-19 or COVID-19 vaccine and thyroid dysfunction can help provide substantial evidence and potential therapeutic targets that can alter prognosis and improve COVID-19 related outcomes in individuals with or without preexisting thyroid disease.
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Details
- Title
- Investigating thyroid dysfunction in the context of COVID-19 infection
- Creators
- Aashna Mehta - University of DebrecenWireko Andrew Awuah - Sumy State UniversityRohan Yarlagadda - Rowan UniversityJacob Kalmanovich - Drexel UniversityHelen Huang - Royal College of Surgeons in IrelandMrinmoy Kundu - Institute of Medical Sciences and Sum HospitalEsther Patience Nansubuga - University of LeedsLeilani Lopes - Pacific Northwest University of Health SciencesBikona Ghosh - Dhaka Medical College and HospitalMohammad Mehedi Hasan - Mawlana Bhashani Science and Technology University
- Publication Details
- Annals of medicine and surgery, v 84, pp 104806-104806
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000892207600014
- Scopus ID
- 2-s2.0-85143156878
- Other Identifier
- 991021901415004721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism