Journal article
Investigation of epstein-barr virus as a potential cause of B-cell non-Hodgkin lymphoma in a prospective cohort
Cancer epidemiology, biomarkers & prevention, v 22(10), pp 1747-1755
Oct 2013
PMID: 23885038
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We hypothesized that poor control of Epstein-Barr virus (EBV) infection, leading to reactivation of the virus, increases the risk of non-Hodgkin lymphoma (NHL) in the general population of primarily immunocompetent persons.
We conducted a case-control study nested within the Women's Health Initiative Observational Study cohort in which we measured antibodies to EBV antigens [immunoglobulin G (IgG) to viral capsid antigen (VCA), nuclear antigen (EBNA1), and early antigen-diffuse (EA-D)] and EBV DNA load in prediagnostic samples of 491 B-cell NHL cases and 491 controls.
We found no association with established EBV infection, based on seropositivity for VCA. Seropositivity for EBNA1 was associated with decreased risk of B-cell NHL, overall [OR = 0.5; 95% confidence interval (CI), 0.3-0.8] and for each of the histologic subtypes examined. Increased risk of chronic lymphocytic leukemia (CLL) and related subtypes was observed with higher levels of EBV DNA and antibody to EA-D, both markers reflective of reactivation. These associations were strongest for cases with the shortest time interval between blood draw and diagnosis.
In balance, these results do not provide strong evidence of EBV playing a causal role in B-cell NHL in general population women. The associations we observed may reflect increased risk of NHL with underlying immune impairment or could be due to reverse causation.
Further characterization of the subtype-specific association with CLL is warranted. Exclusion of cases with preclinical disease markers (such as monoclonal B-lymphocytosis for CLL) may help rule out reverse causation in future studies.
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Details
- Title
- Investigation of epstein-barr virus as a potential cause of B-cell non-Hodgkin lymphoma in a prospective cohort
- Creators
- Anneclaire J De Roos - Drexel UniversityOtoniel Martínez-Maza - Obstetrics & Gynecology, and Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine,Keith R Jerome - University of WashingtonDana K Mirick - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaKenneth J Kopecky - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaMargaret M Madeleine - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaLarry Magpantay - University of California, Los AngelesKerstin L Edlefsen - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaAndrea Z Lacroix - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 22(10), pp 1747-1755
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN268200900008C / PHS HHS HHSN271201100004C / PHS HHS HHSN268200900008C / WHI NIH HHS HHSN268201100003C / PHS HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100004C / PHS HHS HHSN268201100002C / PHS HHS HHSN268201100003C / WHI NIH HHS HHSN268201100001C / PHS HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000325631200011
- Scopus ID
- 2-s2.0-84886419809
- Other Identifier
- 991019169913604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health