Journal article
Investigations of electrospray sample deposition for polymer MALDI mass spectrometry
Journal of the American Society for Mass Spectrometry, v 15(2), pp 168-179
2004
PMID: 14766284
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In the interest of a more thorough understanding of the relationship between sample deposition technique and the quality of data obtained using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, details of the electrospray (ES) process of sample deposition are investigated using a number of techniques. Sample morphology was observed with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while matrix-enhanced secondary ion mass spectrometry (MESIMS) monitored surface coverage. Electrospray deposition reduces the analyte segregation that can occur during traditional dried droplet deposition for MALDI. We attribute statistically significant improvements in the reproducibility of signal intensity and MALDI average molecular mass measurements to the ES sample deposition technique.
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Details
- Title
- Investigations of electrospray sample deposition for polymer MALDI mass spectrometry
- Creators
- Scott D Hanton - Air Products and Chemicals, Inc., Allentown, Pennsylvania, USAIngrid Z Hyder - Air Products and Chemicals, Inc., Allentown, Pennsylvania, USAJames R Stets - Air Products and Chemicals, Inc., Allentown, Pennsylvania, USAKevin G Owens - Department of Chemistry, Drexel Univiersity, Philadelphia, Pennsylvania, USAWilliam R Blair - Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USACharles M Guttman - Polymers Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USAAnthony A Giuseppetti - American Dental Association Health Foundation-Paffenbarger Research Center, Gaithersburg, Maryland, USA
- Publication Details
- Journal of the American Society for Mass Spectrometry, v 15(2), pp 168-179
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000188825600005
- Scopus ID
- 2-s2.0-0842332042
- Other Identifier
- 991014878332504721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Chemistry, Analytical
- Chemistry, Physical
- Spectroscopy