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Journal article
Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study
The Lancet. Haematology, v 2(7), pp E276-E281
01 Jul 2015
PMID: 26436129
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background There is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted low-dose radiation exposure typical of occupational, environmental, and diagnostic medical settings. We quantified associations between protracted low-dose radiation exposures and leukaemia, lymphoma, and multiple myeloma mortality among radiation-monitored adults employed in France, the UK, and the USA.
Methods We assembled a cohort of 308 297 radiation-monitored workers employed for at least 1 year by the Atomic Energy Commission, AREVA Nuclear Cycle, or the National Electricity Company in France, the Departments of Energy and Defence in the USA, and nuclear industry employers included in the National Registry for Radiation Workers in the UK. The cohort was followed up for a total of 8 . 22 million person-years. We ascertained deaths caused by leukaemia, lymphoma, and multiple myeloma. We used Poisson regression to quantify associations between estimated red bone marrow absorbed dose and leukaemia and lymphoma mortality.
Findings Doses were accrued at very low rates (mean 1.1 mGy per year, SD 2.6). The excess relative risk of leukaemia mortality (excluding chronic lymphocytic leukaemia) was 2.96 per Gy (90% CI 1.17-5.21; lagged 2 years), most notably because of an association between radiation dose and mortality from chronic myeloid leukaemia (excess relative risk per Gy 10.45, 90% CI 4.48-19.65).
Interpretation This study provides strong evidence of positive associations between protracted low-dose radiation exposure and leukaemia.
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Details
- Title
- Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study
- Creators
- Klervi Leuraud - Institut de Radioprotection et de Sûreté NucléaireDavid B. Richardson - University of North Carolina at Chapel HillElisabeth Cardis - Pompeu Fabra UniversityRobert D. Daniels - National Institute for Occupational Safety and HealthMichael Gillies - Public Health EnglandJacqueline A. O'Hagan - Public Health EnglandGhassan B. Hamra - Drexel UniversityRichard Haylock - Public Health EnglandDominique Laurier - Institut de Radioprotection et de Sûreté NucléaireMonika Moissonnier - Centre International de Recherche sur le CancerMary K. Schubauer-Berigan - National Institute for Occupational Safety and HealthIsabelle Thierry-Chef - Centre International de Recherche sur le CancerAusrele Kesminiene - Centre International de Recherche sur le Cancer
- Publication Details
- The Lancet. Haematology, v 2(7), pp E276-E281
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- Electricite de France US Department of Health and Human Service AREVA 2012-02-21-01 / Ministry of Health, Labour and Welfare of Japan; Ministry of Health, Labour and Welfare, Japan 5R03 0H010056-02 / Centers for Disease Control and Prevention; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA R03 OH-010056 / US Department of Energy through University of North Carolina from the National Institute for Occupational Safety and Health National Institute for Occupational Safety and Health; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) US Department of Energy; United States Department of Energy (DOE)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000362073500006
- Scopus ID
- 2-s2.0-84955727470
- Other Identifier
- 991021863001704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Hematology