Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Ipsi- and Contralateral Oligo- and Polysynaptic Reflexes in Humans Revealed by Low-Frequency Epidural Electrical Stimulation of the Lumbar Spinal Cord
Brain sciences, v 11(1), pp 1-24
16 Jan 2021
PMID: 33467053
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Epidural electrical stimulation (EES) applied over the human lumbosacral spinal cord provides access to afferent fibers from virtually all lower-extremity nerves. These afferents connect to spinal networks that play a pivotal role in the control of locomotion. Studying EES-evoked responses mediated through these networks can identify some of their functional components. We here analyzed electromyographic (EMG) responses evoked by low-frequency (2-6 Hz) EES derived from eight individuals with chronic, motor complete spinal cord injury. We identified and separately analyzed three previously undescribed response types: first, crossed reflexes with onset latencies of ~55 ms evoked in the hamstrings; second, oligosynaptic reflexes within 50 ms post-stimulus superimposed on the monosynaptic posterior root-muscle reflexes in the flexor muscle tibialis anterior, but with higher thresholds and no rate-sensitive depression; third, polysynaptic responses with variable EMG shapes within 50-450 ms post-stimulus evoked in the tibialis anterior and triceps surae, some of which demonstrated consistent changes in latencies with graded EES. Our observations suggest the activation of commissural neurons, lumbar propriospinal interneurons, and components of the late flexion reflex circuits through group I and II proprioceptive afferent inputs. These potential neural underpinnings have all been related to spinal locomotion in experimental studies.
Metrics
Details
- Title
- Ipsi- and Contralateral Oligo- and Polysynaptic Reflexes in Humans Revealed by Low-Frequency Epidural Electrical Stimulation of the Lumbar Spinal Cord
- Creators
- Ursula S Hofstoetter - Medical University of ViennaSimon M Danner - Drexel UniversityBrigitta Freundl - Wiener KrankenanstaltenverbundHeinrich Binder - Wiener KrankenanstaltenverbundPeter Lackner - Wiener KrankenanstaltenverbundKaren Minassian - Medical University of Vienna
- Publication Details
- Brain sciences, v 11(1), pp 1-24
- Publisher
- MDPI
- Grant note
- R01 NS115900 / NINDS NIH HHS I 3837-B34 / Austrian Science Fund R01 NS112304 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000611030300001
- Scopus ID
- 2-s2.0-85099858195
- Other Identifier
- 991019167601804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences