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Journal article
Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling
International journal of molecular sciences, v 23(10), p5541
16 May 2022
PMID: 35628347
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We describe and analyze a computational model of neural circuits in the mammalian spinal cord responsible for generating and shaping locomotor-like oscillations. The model represents interacting populations of spinal neurons, including the neurons that were genetically identified and characterized in a series of previous experimental studies. Here, we specifically focus on the ipsilaterally projecting V1 interneurons, their possible role in the spinal locomotor circuitry, and their involvement in the generation of locomotor oscillations. The proposed connections of these neurons and their involvement in different neuronal pathways in the spinal cord allow the model to reproduce the results of optogenetic manipulations of these neurons under different experimental conditions. We suggest the existence of two distinct populations of V1 interneurons mediating different ipsilateral and contralateral interactions within the spinal cord. The model proposes explanations for multiple experimental data concerning the effects of optogenetic silencing and activation of V1 interneurons on the frequency of locomotor oscillations in the intact cord and hemicord under different experimental conditions. Our simulations provide an important insight into the organization of locomotor circuitry in the mammalian spinal cord.
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Details
- Title
- Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling
- Creators
- Natalia A Shevtsova - Drexel UniversityErik Z Li - Drexel UniversityShayna Singh - Drexel UniversityKimberly J Dougherty - Drexel UniversityIlya A Rybak - Drexel University
- Publication Details
- International journal of molecular sciences, v 23(10), p5541
- Publisher
- MDPI
- Grant note
- R01NS095366; R01NS104194; R01NS110550; R01NS112304; F30NS110199; T32NS121768 / NIH HHS 2113069 / National Science Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000801479300001
- Scopus ID
- 2-s2.0-85130632964
- Other Identifier
- 991019169008804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary