Journal article
Irradiation Toxic Effects During Intra-arterial Chemotherapy for Retinoblastoma Should We Be Concerned?
Archives of ophthalmology (1960), v 128(11), pp 1427-1431
01 Nov 2010
PMID: 21060044
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Abstract
Objective: To evaluate irradiation toxic effects from fluoroscopy during intra-arterial chemotherapy for retinoblastoma.
Design: Prospective trial.
Participants: Eight patients treated with intra-arterial chemotherapy.
Main Outcome Measures: Irradiation toxic effects in vital organs.
Results: The mean patient age was 29 months (range, 10-74 months) and 63% were male. The mean irradiation dose to the skin of the affected eye was 0.19173 Gy, to the contralateral eye was 0.03533 Gy, to the chest wall was 0.00296 Gy, and to the abdominal wall was 0.00104 Gy. The estimated irradiation dose to the lens in the treatment eye was 0.16 Gy, which, in accumulated doses, could be cataractogenic. The estimated irradiation dose from a single fluoroscopy session to other organs, including the brain (0.05560 Gy), thyroid (0.00192 Gy), bone marrow (0.00059 Gy), and gonads (0.00015 Gy), was far lower than the minimal toxic level.
Conclusions: Careful use of fluoroscopy during intra-arterial chemotherapy with limited irradiation exposure is advised. Accumulated irradiation toxic effects following multiple sessions of intra-arterial chemotherapy could be cataractogenic and possibly carcinogenic, especially in irradiation-sensitive patients with retinoblastoma.
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Details
- Title
- Irradiation Toxic Effects During Intra-arterial Chemotherapy for Retinoblastoma Should We Be Concerned?
- Creators
- Rajakrishnan Vijayakrishnan - Saint Vincent HospitalCarol L. Shields - Wills Eye Inst, Ocular Oncol Serv, Philadelphia, PA 19107 USAAparna Ramasubramanian - Wills Eye Inst, Ocular Oncol Serv, Philadelphia, PA 19107 USAJacqueline Emrich - Hahnemann Hosp, Dept Radiat Oncol, Philadelphia, PA USARobert Rosenwasser - Thomas Jefferson Univ, Dept Cerebrovasc Surg, Philadelphia, PA 19107 USAJerry A. Shields - Wills Eye Inst, Ocular Oncol Serv, Philadelphia, PA 19107 USA
- Publication Details
- Archives of ophthalmology (1960), v 128(11), pp 1427-1431
- Publisher
- Amer Medical Assoc
- Number of pages
- 5
- Grant note
- Eye Tumor Research Foundation, Philadelphia, Pennsylvania LuEsther Mertz Retina Research Foundation, New York, New York Retina Research Foundation of the Retina Society in Cape Town, South Africa Paul Kayser International Award of Merit in Retina Research, Houston, Texas
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:000283932600006
- Scopus ID
- 2-s2.0-77955382541
- Other Identifier
- 991019168769204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology