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Irreversible neurologic degeneration secondary to vitamin B12 deficiency without anemia: report of a case
Journal article   Open access   Peer reviewed

Irreversible neurologic degeneration secondary to vitamin B12 deficiency without anemia: report of a case

Barry M Krein, Juan Troncoso, S Benham Kahn and Elliott L Mancall
The Journal of the American Osteopathic Association, v 84(4), pp 348-350
01 Dec 1984
PMID: 6511511
url
https://doi.org/10.1515/jom-1984-841215View
Published, Version of Record (VoR) Restricted CC BY-NC-ND V4.0

Abstract

A patient with undiagnosed pernicious anemia presented with progressively severe neurologic manifestations of 6-months' duration. The neurologic symptoms had worsened abruptly after prolonged exposure to heat; this is a previously unreported event in cases of subacute combined degeneration of the spinal cord. Previous failure to recognize macrocytosis, which may appear well before the decrease in hemoglobin concentration, as an early sign of pernicious anemia resulted in delay of diagnosis and irreversible neurologic damage.

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Medicine, General & Internal
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