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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Is There a Threshold Oral Glucose Tolerance Test Value for Predicting Adverse Pregnancy Outcome?
American journal of perinatology, v 32(9), pp 833-838
01 Jul 2015
PMID: 25594222
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective This study aims to determine whether there is a threshold 3-hour oral glucose tolerance test (OGTT) value associated with accelerated risk of adverse pregnancy outcomes.
Study Design In a secondary analysis of a cohort of women with untreated mild gestational glucose intolerance, we used generalized additive models with smoothing splines to explore nonlinear associations between each of the 3-hour OGTT values (fasting, 1-hour, 2-hour, and 3-hour) and adverse pregnancy outcomes, including the study's composite outcome (perinatal mortality, hypoglycemia, hyperbilirubinemia, neonatal hyperinsulinemia, and/or birth trauma), large for gestational age birth weight, small for gestational age birth weight, shoulder dystocia, neonatal hypoglycemia, gestational hypertension (gHTN), and preeclampsia.
Results Among the 1,360 eligible women, each timed OGTT value was linearly associated with increased odds of composite adverse outcome. We found evidence of a departure from linearity only for the association between fasting glucose and gHTN/preeclampsia, with a stronger association for values of 85 to 94 mg/dL (p = 0.03). We found no evidence of departure from linearity for any other OGTT values and measured outcomes (all chi-square test p-values >= 0.05).
Conclusion In a population of untreated women with mild gestational glucose intolerance and fasting OGTT < 95 mg/dL, we found an increasing risk of gHTN with a fasting glucose between 85 and 94 mg/dL.
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Details
- Title
- Is There a Threshold Oral Glucose Tolerance Test Value for Predicting Adverse Pregnancy Outcome?
- Creators
- Alison M. Stuebe - University of North CarolinaMark B. Landon - The Ohio State UniversityYinglei Lai - George Washington UniversityMark Klebanoff - Nationwide Children's HospitalSusan M. Ramin - The University of Texas Health Science Center at HoustonRonald J. Wapner - Columbia UniversityMichael W. Varner - University of UtahDwight J. Rouse - University of Alabama at BirminghamAnthony Sciscione - Drexel UniversityPatrick Catalano - Case Western Reserve UniversityGeorge Saade - The University of Texas Medical Branch at GalvestonYoram Sorokin - Wayne State UniversityAlan M. Peaceman - Northwestern UniversityEunice Kennedy Shriver Natl InstYiling Lai - Design
- Publication Details
- American journal of perinatology, v 32(9), pp 833-838
- Publisher
- Thieme Medical Publishers
- Number of pages
- 6
- Grant note
- UG1HD040545 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U01HD021410 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) M01-RR00034 / General Clinical Research Centers; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) HD27915,; HD34116,; HD40485,; HD34208,; HD27869,; HD40500,; HD40560,; HD34136,; HD40544,; HD27860; HD40545; HD53097; HD21410; HD27917; HD40512; HD53118; HD36801 / Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UL1RR024989; M01-RR00080; UL1-RR025764; C06-RR11234 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) UL1TR000439 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) C06RR011234 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Design
- Web of Science ID
- WOS:000358571000005
- Scopus ID
- 2-s2.0-84938061844
- Other Identifier
- 991019173443504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Obstetrics & Gynecology
- Pediatrics