Journal article
Is it isomerization of cobalamins or simple hydrolysis of a propionamide side chain?
Inorganica Chimica Acta, v 136(2), pp 75-79
1987
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Abstract
Literature is replete with references to b-, d-, and e-monocarboxylic acids of cobalamin, supposedly resulting from hydrolysis of a propionamide side chain. Out work indicates that these species are not monocarboxylic acids but isomers of cobalamins. The ease of isomerization under mild conditions, its reversibility, the formation of intermediate(s), large interconversions between the new isomers, b-, d-, and e-B
12′ and the observation using high resolution mass spectrometry that the molecular mass of protonated d-B
12′ is identical to B
12, all attest to genuine isomerization. Significant changes, in the puckering of the corrin ring, and in other parts of the molecule are clearly revealed by our earlier Mössbauer, proton and phosphorus nuclear magnetic resonance investigations, and as well as by the more recent carbon-13 and crystal structure studies reported in the literature.
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Details
- Title
- Is it isomerization of cobalamins or simple hydrolysis of a propionamide side chain?
- Creators
- Rakesh K. Kohli - Drexel UniversityAmar Nath - Drexel University
- Publication Details
- Inorganica Chimica Acta, v 136(2), pp 75-79
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- [Retired Faculty]
- Web of Science ID
- WOS:A1987H314700003
- Scopus ID
- 2-s2.0-0345048216
- Other Identifier
- 991019174009404721
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- Web of Science research areas
- Chemistry, Inorganic & Nuclear