Journal article
Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?
Pharmacological research, v 163, 105211
01 Jan 2021
PMID: 33010423
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
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Mitochondrial dysfunction – including increased apoptosis, calcium and protein dyshomeostasis within the organelle, and dysfunctional bioenergetics and oxidative status – is a common, early feature in all the major neurodegenerative diseases, including Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). However, the exact molecular mechanisms that drive the organelle to dysfunction and ultimately to failure in these conditions are still not well described. Different authors have shown that inorganic polyphosphate (polyP), an ancient and well-conserved molecule, plays a key role in the regulation of mitochondrial physiology under basal conditions. PolyP, which is present in all studied organisms, is composed of chains of orthophosphates linked together by highly energetic phosphoanhydride bonds, similar to those found in ATP. This polymer shows a ubiquitous distribution, even if a high co-localization with mitochondria has been reported. It has been proposed that polyP might be an alternative to ATP for cellular energy storage in different organisms, as well as the implication of polyP in the regulation of many of the mitochondrial processes affected in AD and PD, including protein and calcium homeostasis. Here, we conduct a comprehensive review and discussion of the bibliography available regarding the role of polyP in the mitochondrial dysfunction present in AD and PD. Taking into account the data presented in this review, we postulate that polyP could be a valid, innovative and, plausible pharmacological target against mitochondrial dysfunction in AD and PD. However, further research should be conducted to better understand the exact role of polyP in neurodegeneration, as well as the metabolism of the polymer, and the effect of different lengths of polyP on cellular and mitochondrial physiology.
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Details
- Title
- Is there a link between inorganic polyphosphate (polyP), mitochondria, and neurodegeneration?
- Creators
- Emily A. Borden - Rutgers, The State University of New JerseyMatthew Furey - Rutgers, The State University of New JerseyNicholas J. Gattone - Rutgers, The State University of New JerseyVedangi D. Hambardikar - Rutgers, The State University of New JerseyXiao Hua Liang - Rutgers, The State University of New JerseyErnest R. Scoma - Rutgers, The State University of New JerseyAntonella Abou Samra - Rutgers, The State University of New JerseyLaKeshia R. D-Gary - Rutgers, The State University of New JerseyDayshaun J. Dennis - Rutgers, The State University of New JerseyDaniel Fricker - Rutgers, The State University of New JerseyCindy Garcia - Rutgers, The State University of New JerseyZeCheng Jiang - Rutgers, The State University of New JerseyShariq A. Khan - Rutgers, The State University of New JerseyDheenadhayalan Kumarasamy - Rutgers, The State University of New JerseyHasmitha Kuppala - Rutgers, The State University of New JerseySavannah Ringrose - Rutgers, The State University of New JerseyEvan J. Rosenheim - Rutgers, The State University of New JerseyKimberly Van Exel - Rutgers, The State University of New JerseyHemanth Sai Vudhayagiri - Rutgers, The State University of New JerseyJiarui Zhang - Rutgers, The State University of New JerseyZhaowen Zhang - Rutgers, The State University of New JerseyMariona Guitart-Mampel - Rutgers, The State University of New JerseyPedro Urquiza - Rutgers, The State University of New JerseyMaria E. Solesio - Rutgers, The State University of New Jersey
- Publication Details
- Pharmacological research, v 163, 105211
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000609226800006
- Scopus ID
- 2-s2.0-85092487746
- Other Identifier
- 991022197451004721
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- Web of Science research areas
- Pharmacology & Pharmacy