Journal article
Isocyanide Purification: C-2 Silica Cleans Up a Dirty Little Secret
Synthesis (Stuttgart), v 51(10), pp 2122-2127
01 May 2019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
EtSiCl3-treated silica gel, C-2 silica,' proved exceptionally effective for purifying isocyanides that are otherwise irreversibly adsorbed during silica gel chromatography. Purification of a prototypical isocyanide on several chromatographic matrices provided valuable insight into the requirements for purifying silica-sensitive isocyanides. EtSiCl3-modified silica proved optimal as the solid phase, providing up to 90% recovery of pure isocyanides that otherwise fail to elute during silica gel purification.
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Details
- Title
- Isocyanide Purification: C-2 Silica Cleans Up a Dirty Little Secret
- Creators
- Allen Chao - Drexel UniversityEmbarek Alwedi - MERCKFraser F. Fleming - Drexel University
- Publication Details
- Synthesis (Stuttgart), v 51(10), pp 2122-2127
- Publisher
- Thieme Medical Publishers
- Number of pages
- 6
- Grant note
- Drexel University
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000467273700007
- Scopus ID
- 2-s2.0-85065163225
- Other Identifier
- 991019168133404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Chemistry, Organic