Journal article
Isocyanoalkene Addition–Cyclization–Decarboxylation Cascades
Synthesis (Stuttgart)
15 Jul 2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract A rare conjugate addition to isocyanoalkenes with ethyl cyanoacetate triggers an efficient addition–cyclization–decarboxylation cascade. Using finely dispersed NaOH in THF as a base and nucleophile, is critical in facilitating the proton transfers, the ester hydrolysis, and the subsequent decarboxylation. The strategy provides an efficient route to valuable nitrile-substituted 2,3-dihydro-1H-pyrroles while providing fundamental insight into conjugate additions to isocyanoalkenes.
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Details
- Title
- Isocyanoalkene Addition–Cyclization–Decarboxylation Cascades
- Creators
- John-Paul R. MarrazzoTish HuynhFraser F. Fleming
- Publication Details
- Synthesis (Stuttgart)
- Publisher
- Thieme
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:001272436500005
- Scopus ID
- 2-s2.0-85219275953
- Other Identifier
- 991021893568804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Organic