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Isolated Cortical Vein Thrombosis Associated with Prothrombin Gene Mutation
Journal article

Isolated Cortical Vein Thrombosis Associated with Prothrombin Gene Mutation

Elias A. Giraldo, Rohan Arora and Robert A. Koenigsberg
Journal of stroke and cerebrovascular diseases, v 23(4), pp 791-793
Apr 2014
DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.06.004
PMID: 23834854
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

cortical vein thrombosis Hemorrhagic stroke inherited thrombophilia prothrombin G20210A gene mutation
Isolated cortical vein thrombosis (ICVT) accounts for less than 1% of strokes. We report a 47-year-old female patient who had a frontal hemorrhage with headache associated with contralateral hemiparesis and hemisensory deficit on presentation. This hemorrhagic stroke was localized in a nonarterial territory, and it was caused by ipsilateral and isolated thrombosis of the vein of Labbe found on catheter angiogram that demonstrated a filling defect of the vein of Labbe at its connection with the transverse sinus. There were no filling defects in the superficial middle cerebral veins. Our patient had a family history of cardiovascular disease, stroke, and factor V Leiden mutation and cigarette smoking as stroke risk factors. Complete prothrombotic state laboratory workup revealed a heterozygous prothrombin G20210 A gene mutation. The patient's hospital course was uneventful. Neurologic exam was normal at stroke clinic follow-up 6 weeks later. To our knowledge, this is the first report of an ICVT associated with prothrombin gene mutation.

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3 citations in Web of Science
2 citations in Scopus

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Web of Science research areas
Neurosciences
Peripheral Vascular Disease
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