Journal article
Isolated Neurosarcoidosis Case Series in 2 Sarcoidosis Centers
The Neurologist (Baltimore, Md.), v 18(6), pp 373-377
01 Nov 2012
PMID: 23114669
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Neurosarcoidosis occurs in the central or peripheral nervous system and is usually associated with other sarcoidosis organ involvement. However, when sarcoidosis develops exclusively in the nervous system, its diagnosis is problematic.
Methods: Retrospective analysis of patients who were histologically diagnosed with neurosarcoidosis without other organ involvement (isolated neurosarcoidosis) at Medical University of South Carolina and Allegheny General Hospital. For comparison, we also collected data from neurosarcoidosis patients with histologic evidence in an extraneural organ (systemic neurosarcoidosis).
Results: Ninety-one cases of neurosarcoidosis were identified with 10 patients having isolated neurosarcoidosis. Common clinical manifestations of the isolated neurosarcoidosis patients were headache (9), paresthesia (5), and cranial neuropathies (4). All isolated neurosarcoidosis patients underwent a biopsy from the central nervous system. The prebiopsy impression included lymphoma (4), tumor (2), and sarcoidosis (2). In all patients, no extranueral sarcoidosis developed during a relatively long follow-up period (mean 58 mo). Compared with the systemic neurosarcoidosis cohort (60), isolated neurosarcoidosis patients had similar demographics and neurological manifestations with a few exceptions including a more common frequency of headache, hemiparesis, and radiculopathy, leptomeningeal involvement on brain MRI, increased cell count in cerebrospinal fluid, and a more favorable clinical outcome (P < 0.05). The duration of follow-up and the number of studies performed to evaluate patients for extraneural sarcoidosis were similar in the 2 cohorts.
Conclusions: The clinical and radiologic features of isolated neurosarcoidosis are similar to those of systemic neurosarcoidosis with a few exceptions. The diagnosis of isolated neurosarcoidosis is problematic and often not considered before biopsy of neural tissue.
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Details
- Title
- Isolated Neurosarcoidosis Case Series in 2 Sarcoidosis Centers
- Creators
- Kenkichi Nozaki - Medical University of South CarolinaThomas F. Scott - Drexel UniversityMimi Sohn - Med Univ S Carolina, Div Neurol, Dept Neurosci, Charleston, SC 29425 USAMarc A. Judson - Albany Med Coll, Div Pulm & Crit Care Med, Albany, NY 12208 USA
- Publication Details
- The Neurologist (Baltimore, Md.), v 18(6), pp 373-377
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000310628800006
- Scopus ID
- 2-s2.0-84869756729
- Other Identifier
- 991019167693004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology