Journal article
Isolated cerebral mucormycosis: A case discussion
IDCases, v 33, e01821
01 Jan 2023
PMID: 37415782
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We report a case of a 32-year-old male with a history of type 1 diabetes, inhaled drug use, and alcohol use disorder, who presented with encephalopathy, holocranial headaches, neck pain, confusion, and generalized tonic-clonic seizures. The patient initially presented at a rural community hospital with a fever and was found to be in diabetic ketoacidosis (DKA). He was also hemodynamically stable but stuporous, prompting intubation to protect his airway. Despite initial treatment measures, his neurological condition worsened and he remained ventilator-dependent. Key findings include a high glucose level, presence of ketones, and evidence of drug use. Blood cultures showed no growth, but his febrile state persisted. Cerebrospinal fluid (CSF) analysis revealed mild pleocytosis, hyperglycorrhachia but normal protein, with no growth. Neuroimaging showed right hemispheric slowing on EEG and diffusion restriction in the right frontal lobe on MRI. The patient's neurological status worsened on the second day of admission, manifesting as sluggish pupillary reflexes, right third nerve palsy, and decerebrate posturing. Emergent MRI suggested cerebral edema, leading to initiation of hypertonic saline. This case highlights the diagnostic challenges and critical management considerations in a patient with multiple comorbidities presenting with unexplained neurological deterioration, emphasizing the importance of a comprehensive and timely approach to diagnosis and treatment.
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Details
- Title
- Isolated cerebral mucormycosis: A case discussion
- Creators
- Harneel Saini - Allegheny General HospitalHarinoor Mann - Allegheny General HospitalRomil Singh - Allegheny General HospitalIshveen Saini - Lake Erie College of Osteopathic MedicineNitin Bhanot - Allegheny General HospitalKevin Kelly - Allegheny General HospitalSandeep Rana - Allegheny General Hospital
- Publication Details
- IDCases, v 33, e01821
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:001024709800001
- Scopus ID
- 2-s2.0-85162195704
- Other Identifier
- 991021959040304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Infectious Diseases