Journal article
Isolating and targeting a highly active, stochastic dendritic cell subpopulation for improved immune responses
Cell reports (Cambridge), v 41(5), pp 111563-111563
01 Nov 2022
PMID: 36323246
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Dendritic cell (DC) activation via pathogen-associated molecular patterns (PAMPs) is critical for antigen pre-sentation and development of adaptive immune responses, but the stochastic distribution of DC responses to PAMP signaling, especially during the initial stages of immune activation, is poorly understood. In this study, we isolate a unique DC subpopulation via preferential phagocytosis of microparticles (MPs) and char-acterize this subpopulation of "first responders"(FRs). We present results that show these cells (1) can be isolated and studied via both increased accumulation of the micron-sized particles and combinations of cell surface markers, (2) show increased responses to PAMPs, (3) facilitate adaptive immune responses by providing the initial paracrine signaling, and (4) can be selectively targeted by vaccines to modulate both anti-body and T cell responses in vivo. This study presents insights into a temporally controlled, distinctive cell population that influences downstream immune responses. Furthermore, it demonstrates potential for improving vaccine designs via FR targeting.
Metrics
Details
- Title
- Isolating and targeting a highly active, stochastic dendritic cell subpopulation for improved immune responses
- Creators
- Peter Deak - University of ChicagoBradley Studnitzer - University of ChicagoTrevor Ung - University of ChicagoRachel Steinhardt - Syracuse UniversityMelody Swartz - University of ChicagoAaron Esser-Kahn - University of Chicago
- Publication Details
- Cell reports (Cambridge), v 41(5), pp 111563-111563
- Publisher
- Elsevier
- Number of pages
- 25
- Grant note
- National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemical and Biological Engineering
- Web of Science ID
- WOS:000884847000006
- Scopus ID
- 2-s2.0-85140928555
- Other Identifier
- 991019520541604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology