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Isolation and sequence analysis of oxytocin from the sheep corpus luteum
Journal article   Peer reviewed

Isolation and sequence analysis of oxytocin from the sheep corpus luteum

W.B. Watkins, V.J. Choy, I.M. Chaiken and J. Spiess
Neuropeptides (Edinburgh), v 7(1), pp 87-95
1986
PMID: 3951682

Abstract

Studies have revealed that the corpus luteum (CL) of the sheep releases oxytocin (OT) -like immunoreactivity under normal and physiological conditions. We have now purified and completely characterized the OT-like species from ovine CL and established by Edman degradation and comparative reverse-phase HPLC its identity with hypothalamic oxytocin. On the basis of radioimmunoassay, the characterized oxytocin was the only peptide possessing OT-like immunoreactivity. This study represents the first identification by sequence analysis of oxytocin outside the central nervous system.

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Endocrinology & Metabolism
Neurosciences
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