Journal article
It cuts two ways: microtubule loss during Alzheimer disease
The EMBO journal, v 32(22), pp 2900-2902
13 Nov 2013
PMID: 24076651
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Microtubule loss contributes to nervous system degeneration during Alzheimer disease. New findings report that abnormal tau invasion into dendrites, triggered by Amyloid β, results in excess severing of microtubules by spastin.
EMBO J
32
:
2920
–
2937
10.1038/emboj.2013.207; published online
09
24
2013
Microtubule loss from axons and dendrites is a key contributor to nervous system degeneration during Alzheimer disease. Previous evidence suggested a simple pathway by which tau dissociation from microtubules in the axon allows excess severing of microtubules by katanin. Now, new evidence has emerged for a more complex pathway by which abnormal tau invasion into dendrites, triggered by A
β
oligomers, results in excess severing of microtubules by spastin.
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Details
- Title
- It cuts two ways: microtubule loss during Alzheimer disease
- Creators
- Daphney C Jean - , Philadelphia, PAPeter W Baas - , Philadelphia, PA
- Publication Details
- The EMBO journal, v 32(22), pp 2900-2902
- Publisher
- Nature Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000326921400002
- Scopus ID
- 2-s2.0-84887824758
- Other Identifier
- 991014877666704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology