Journal article
Ivabradine-Induced Bradycardia is Accompanied by Reduced Stress-Related Anxiety
American journal of hypertension, v 36(6), pp 316-323
21 May 2023
PMID: 36812223
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hypertensive individuals with higher heart rates and anxiety have greater cardiovascular morbidity and mortality. Despite the correlation between hypertension, heart rate, and anxiety, scant attention has been paid to the effect of hypertension drug therapy on behavioral outcomes in cardiovascular disease. Ivabradine, an inhibitor of hyperpolarization-activated, cyclic nucleotide-gated funny channels (HCNs), has been used clinically to reduce heart rates and has been shown to improve quality of life in patients with angina and heart failure. We postulated that in addition to lowering heart rate, ivabradine could reduce anxiety in mice exposed to a significant stress paradigm.
Mice underwent a stress induction protocol, subsequently they received either vehicle or ivabradine (10 mg/kg) via osmotic minipumps. Blood pressure and heart rates were measured with tail cuff photoplethysmography. Anxiety was assessed quantitatively through the open field test (OFT) and the elevated plus maze (EPM). Cognition was assessed with an object recognition test (ORT). Pain tolerance was measured by the hot plate test or subcutaneous injection of formalin. HCN gene expression was measured with RT-PCR.
Ivabradine reduced resting heart rate in the stressed mice by 22%. Stressed mice treated with ivabradine displayed significantly greater exploratory behavior in the OFT, EPM, and ORT. The expression of central HCN channels was significantly reduced following stress.
It is suggested from our findings that ivabradine can reduce anxiety following significant psychological stress. Reductions in heart rate may directly improve quality of life by reducing anxiety in patients with hypertension and high heart rates.
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Details
- Title
- Ivabradine-Induced Bradycardia is Accompanied by Reduced Stress-Related Anxiety
- Creators
- Ryan Woodman (Corresponding Author) - University of California, DavisJeffrey Student - Drexel UniversityColeman Miller - University of MissouriWarren Lockette - Wayne State University
- Publication Details
- American journal of hypertension, v 36(6), pp 316-323
- Publisher
- Oxford University Press
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000953576800001
- Scopus ID
- 2-s2.0-85159790295
- Other Identifier
- 991021860716504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Peripheral Vascular Disease