Journal article
Job Strain and the Cortisol Diurnal Cycle in MESA: Accounting for Between- and Within-Day Variability
American journal of epidemiology, v 183(5), pp 497-506
01 Mar 2016
PMID: 26905339
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence of the link between job strain and cortisol levels has been inconsistent. This could be due to failure to account for cortisol variability leading to underestimated standard errors. Our objective was to model the relationship between job strain and the whole cortisol curve, accounting for sources of cortisol variability. Our functional mixed-model approach incorporated all available data -- 18 samples over 3 days -- and uncertainty in estimated relationships. We used employed participants from the Multi-Ethnic Study of Atherosclerosis Stress I Study and data collected between 2002 and 2006. We used propensity score matching on an extensive set of variables to control for sources of confounding. We found that job strain was associated with lower salivary cortisol levels and lower total area under the curve. We found no relationship between job strain and the cortisol awakening response. Our findings differed from those of several previous studies. It is plausible that our results were unique to middle- to older-aged racially, ethnically, and occupationally diverse adults and were therefore not inconsistent with previous research among younger, mostly white samples. However, it is also plausible that previous findings were influenced by residual confounding and failure to propagate uncertainty (i.e., account for the multiple sources of variability) in estimating cortisol features.
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Details
- Title
- Job Strain and the Cortisol Diurnal Cycle in MESA: Accounting for Between- and Within-Day Variability
- Creators
- Kara Rudolph - Johns Hopkins UniversityBrisa Sánchez - University of MichiganElizabeth Stuart - Johns Hopkins UniversityBenjamin Greenberg - University of California, San FranciscoKaori Fujishiro - National Institute for Occupational Safety and HealthGary Wand - Johns Hopkins UniversitySandi Shrager - University of WashingtonTeresa Seeman - University of California at Los AngelesAna Diez RouxSherita Golden - Johns Hopkins University
- Publication Details
- American journal of epidemiology, v 183(5), pp 497-506
- Publisher
- Oxford Publishing Limited (England)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000371688800026
- Scopus ID
- 2-s2.0-84960369481
- Other Identifier
- 991019238584604721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Public, Environmental & Occupational Health