Journal article
KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2
Oncogene, v 35(16), pp 2040-2051
21 Apr 2016
PMID: 26189798
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and basal-like breast cancers. However, the mechanism by which KLF5 promotes cell migration and invasion is still not completely understood. In this study, we demonstrate that TNFAIP2, a tumor necrosis factor-α (TNFα)-induced gene, is a direct KLF5 target gene. The expression of TNFAIP2 is highly correlated with the expression of KLF5 in breast cancers. The manipulation of KLF5 expression positively alters TNFAIP2 expression levels. KLF5 directly binds to the TNFAIP2 gene promoter and activates its transcription. Functionally, KLF5 promotes cancer cell proliferation, migration and invasion in part through TNFAIP2. TNFAIP2 interacts with the two small GTPases Rac1 and Cdc42, thereby increasing their activities to change actin cytoskeleton and cell morphology. These findings collectively suggest that TNFAIP2 is a direct KLF5 target gene, and both KLF5 and TNFAIP2 promote breast cancer cell proliferation, migration and invasion through Rac1 and Cdc42.
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Details
- Title
- KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2
- Creators
- L Jia - Kunming Institute of ZoologyZ Zhou - Kunming Institute of ZoologyH Liang - Kunming Institute of ZoologyJ Wu - Kunming Medical UniversityP Shi - Kunming Institute of ZoologyF Li - Kunming Institute of ZoologyZ Wang - Kunming Institute of ZoologyC Wang - First Affiliated Hospital of Kunming Medical UniversityW Chen - Kunming Medical UniversityH Zhang - Kunming Institute of ZoologyY Wang - Kunming Medical UniversityR Liu - Kunming Institute of ZoologyJ Feng - Department of Laboratory Medicine & Central Laboratory, Southern Medical University-Affiliated Fengxian Hospital, Shanghai, China.C Chen - Kunming Institute of Zoology
- Publication Details
- Oncogene, v 35(16), pp 2040-2051
- Publisher
- Springer Nature
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000374505600004
- Scopus ID
- 2-s2.0-84937611503
- Other Identifier
- 991019320711204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Genetics & Heredity
- Oncology